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2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience
BACKGROUND: The index to ring finger length (2D:4D) ratio is a proxy biomarker for prenatal exposure of sex hormones. Sex hormones are associated with the pathogenesis of ischemic stroke. The purpose of the study was to demonstrate the association between 2D:4D and ischemic stroke. METHODOLOGY: This...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234475/ https://www.ncbi.nlm.nih.gov/pubmed/30479845 http://dx.doi.org/10.1515/tnsci-2018-0021 |
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author | Yang, Ke Ding, XianHui Zhou, ZhiMing Shi, XiaoLei |
author_facet | Yang, Ke Ding, XianHui Zhou, ZhiMing Shi, XiaoLei |
author_sort | Yang, Ke |
collection | PubMed |
description | BACKGROUND: The index to ring finger length (2D:4D) ratio is a proxy biomarker for prenatal exposure of sex hormones. Sex hormones are associated with the pathogenesis of ischemic stroke. The purpose of the study was to demonstrate the association between 2D:4D and ischemic stroke. METHODOLOGY: This study retrospectively reviewed the data of 100 patients with first ever ischemic stroke between September, 2016 and June, 2017. The lengths of index finger and ring finger of both hands were measured using electronic calipers and calculated for 2D:4D ratios. Receive operating characteristic (ROC) mode was used to detect predicting performance of 2D:4D ratios for ischemic stroke. RESULTS: 2D:4D ratios in ischemic stroke patients were higher than controls in both hands (P < 0.05), except right 2D:4D ratio in females. The ROC analyses showed that the area under the curve (AUC) were 0.635 (95%CI: 0.527-0.743) for left 2D:4D ratio, and 0.647 for right (95%CI: 0.539-0.755) (P < 0.05). The AUC of left and right 2D:4D ratio in male were 0.667 (95%CI: 0.514-0.820) and 0.670 (95%CI: 0.519-0.822) (P < 0.05). In female, no significance were found in ROC analysis. And there were no correlation between 2D:4D value and stroke severity (P > 0.05). CONCLUSIONS: The current study indicated that the diagnostic value of 2D:4D ratio was limited in ischemic stroke. Further research is required to explore the role of it in screening ischemic stroke. |
format | Online Article Text |
id | pubmed-6234475 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-62344752018-11-26 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience Yang, Ke Ding, XianHui Zhou, ZhiMing Shi, XiaoLei Transl Neurosci Regular Articles BACKGROUND: The index to ring finger length (2D:4D) ratio is a proxy biomarker for prenatal exposure of sex hormones. Sex hormones are associated with the pathogenesis of ischemic stroke. The purpose of the study was to demonstrate the association between 2D:4D and ischemic stroke. METHODOLOGY: This study retrospectively reviewed the data of 100 patients with first ever ischemic stroke between September, 2016 and June, 2017. The lengths of index finger and ring finger of both hands were measured using electronic calipers and calculated for 2D:4D ratios. Receive operating characteristic (ROC) mode was used to detect predicting performance of 2D:4D ratios for ischemic stroke. RESULTS: 2D:4D ratios in ischemic stroke patients were higher than controls in both hands (P < 0.05), except right 2D:4D ratio in females. The ROC analyses showed that the area under the curve (AUC) were 0.635 (95%CI: 0.527-0.743) for left 2D:4D ratio, and 0.647 for right (95%CI: 0.539-0.755) (P < 0.05). The AUC of left and right 2D:4D ratio in male were 0.667 (95%CI: 0.514-0.820) and 0.670 (95%CI: 0.519-0.822) (P < 0.05). In female, no significance were found in ROC analysis. And there were no correlation between 2D:4D value and stroke severity (P > 0.05). CONCLUSIONS: The current study indicated that the diagnostic value of 2D:4D ratio was limited in ischemic stroke. Further research is required to explore the role of it in screening ischemic stroke. De Gruyter 2018-11-12 /pmc/articles/PMC6234475/ /pubmed/30479845 http://dx.doi.org/10.1515/tnsci-2018-0021 Text en © 2018 Ke Yang et al., published by De Gruyter http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License. |
spellingShingle | Regular Articles Yang, Ke Ding, XianHui Zhou, ZhiMing Shi, XiaoLei 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience |
title | 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience |
title_full | 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience |
title_fullStr | 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience |
title_full_unstemmed | 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience |
title_short | 2D:4D Ratio Differs in Ischemic Stroke: A Single Center Experience |
title_sort | 2d:4d ratio differs in ischemic stroke: a single center experience |
topic | Regular Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234475/ https://www.ncbi.nlm.nih.gov/pubmed/30479845 http://dx.doi.org/10.1515/tnsci-2018-0021 |
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