Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function

Hyperactivating mutations in the non-receptor tyro-sine phosphatase SHP2 cause Noonan syndrome (NS). NS is associated with cognitive deficits, but how hyperactivation of SHP2 in NS changes neuron function is not well understood. We find that mice bearing an NS-associated SHP2 allele (NS mice) have s...

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Detalles Bibliográficos
Autores principales: Levy, Aaron D., Xiao, Xiao, Shaw, Juliana E., Sudarsana Devi, Suma Priya, Katrancha, Sara Marie, Bennett, Anton M., Greer, Charles A., Howe, James R., Machida, Kazuya, Koleske, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234505/
https://www.ncbi.nlm.nih.gov/pubmed/30089263
http://dx.doi.org/10.1016/j.celrep.2018.07.006

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