Cargando…

A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs

Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR...

Descripción completa

Detalles Bibliográficos
Autores principales: Farjadian, Fatemeh, Azadi, Soha, Mohammadi-Samani, Soliman, Ashrafi, Hajar, Azadi, Amir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234517/
https://www.ncbi.nlm.nih.gov/pubmed/30456326
http://dx.doi.org/10.1016/j.heliyon.2018.e00930
_version_ 1783370707773685760
author Farjadian, Fatemeh
Azadi, Soha
Mohammadi-Samani, Soliman
Ashrafi, Hajar
Azadi, Amir
author_facet Farjadian, Fatemeh
Azadi, Soha
Mohammadi-Samani, Soliman
Ashrafi, Hajar
Azadi, Amir
author_sort Farjadian, Fatemeh
collection PubMed
description Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR spectrum confirmed the presence of amine group and CHN analysis determined the amount of organic layer. The high surface area (750 m(2)/g) was determined by applying nitrogen adsorption-desorption technique. The morphology was examined by scanning electron microscopy which proved hexagonal structure. The crystallinity of mesoporous material was observed in XRD pattern of this material. According to previous background of such material in adsorbing drug, herein, the efficiency of this material in adsorbing of 5-fluorouracil was evaluated through solid phase extraction method in aqueous and plasma media with high performance liquid chromatography. The extraction efficiency was evaluated for drug concentrations of 500–2000 ng/ml by means of 5–20 mg/ml hexagonal mesoporous silica in both media. The results showed good to excellent recovery rate of in both aqueous and plasma medium which confirmed that the aminopropyl functionalized hexagonal mesoporous silica could be considered as promising device for drug bioanalysis.
format Online
Article
Text
id pubmed-6234517
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-62345172018-11-19 A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs Farjadian, Fatemeh Azadi, Soha Mohammadi-Samani, Soliman Ashrafi, Hajar Azadi, Amir Heliyon Article Mesoporous silica with hexagonal type structure containing amine functional group was introduced. Firstly, aminopropyl hexagonal mesoporous silica was synthetized in a co-condensation process, via templating route of n-dodecylamine. Then synthesized mesoporous material were characterized, and FT-IR spectrum confirmed the presence of amine group and CHN analysis determined the amount of organic layer. The high surface area (750 m(2)/g) was determined by applying nitrogen adsorption-desorption technique. The morphology was examined by scanning electron microscopy which proved hexagonal structure. The crystallinity of mesoporous material was observed in XRD pattern of this material. According to previous background of such material in adsorbing drug, herein, the efficiency of this material in adsorbing of 5-fluorouracil was evaluated through solid phase extraction method in aqueous and plasma media with high performance liquid chromatography. The extraction efficiency was evaluated for drug concentrations of 500–2000 ng/ml by means of 5–20 mg/ml hexagonal mesoporous silica in both media. The results showed good to excellent recovery rate of in both aqueous and plasma medium which confirmed that the aminopropyl functionalized hexagonal mesoporous silica could be considered as promising device for drug bioanalysis. Elsevier 2018-11-12 /pmc/articles/PMC6234517/ /pubmed/30456326 http://dx.doi.org/10.1016/j.heliyon.2018.e00930 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Farjadian, Fatemeh
Azadi, Soha
Mohammadi-Samani, Soliman
Ashrafi, Hajar
Azadi, Amir
A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_full A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_fullStr A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_full_unstemmed A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_short A novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
title_sort novel approach to the application of hexagonal mesoporous silica in solid-phase extraction of drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234517/
https://www.ncbi.nlm.nih.gov/pubmed/30456326
http://dx.doi.org/10.1016/j.heliyon.2018.e00930
work_keys_str_mv AT farjadianfatemeh anovelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT azadisoha anovelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT mohammadisamanisoliman anovelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT ashrafihajar anovelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT azadiamir anovelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT farjadianfatemeh novelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT azadisoha novelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT mohammadisamanisoliman novelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT ashrafihajar novelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs
AT azadiamir novelapproachtotheapplicationofhexagonalmesoporoussilicainsolidphaseextractionofdrugs