Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension

This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary va...

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Autores principales: Yoshida, Keimei, Saku, Keita, Kamada, Kazuhiro, Abe, Kohtaro, Tanaka-Ishikawa, Mariko, Tohyama, Takeshi, Nishikawa, Takuya, Kishi, Takuya, Sunagawa, Kenji, Tsutsui, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234524/
https://www.ncbi.nlm.nih.gov/pubmed/30456337
http://dx.doi.org/10.1016/j.jacbts.2018.07.007
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author Yoshida, Keimei
Saku, Keita
Kamada, Kazuhiro
Abe, Kohtaro
Tanaka-Ishikawa, Mariko
Tohyama, Takeshi
Nishikawa, Takuya
Kishi, Takuya
Sunagawa, Kenji
Tsutsui, Hiroyuki
author_facet Yoshida, Keimei
Saku, Keita
Kamada, Kazuhiro
Abe, Kohtaro
Tanaka-Ishikawa, Mariko
Tohyama, Takeshi
Nishikawa, Takuya
Kishi, Takuya
Sunagawa, Kenji
Tsutsui, Hiroyuki
author_sort Yoshida, Keimei
collection PubMed
description This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension.
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spelling pubmed-62345242018-11-19 Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension Yoshida, Keimei Saku, Keita Kamada, Kazuhiro Abe, Kohtaro Tanaka-Ishikawa, Mariko Tohyama, Takeshi Nishikawa, Takuya Kishi, Takuya Sunagawa, Kenji Tsutsui, Hiroyuki JACC Basic Transl Sci PRECLINICAL RESEARCH This study aimed to elucidate the therapeutic effects of electrical vagal nerve stimulation (VNS) on severe pulmonary arterial hypertension in a rat model. In a pathophysiological study, VNS significantly restored autonomic balance, decreased mean pulmonary arterial pressure, attenuated pulmonary vascular remodeling, and preserved right ventricular function. In a survival study, VNS significantly improved the survival rate in both the prevention (VNS from 0 to 5 weeks after a SU5416 injection) and treatment (VNS from 5 to 10 weeks) protocols. Thus, VNS may serve as a novel therapeutic strategy for pulmonary arterial hypertension. Elsevier 2018-11-12 /pmc/articles/PMC6234524/ /pubmed/30456337 http://dx.doi.org/10.1016/j.jacbts.2018.07.007 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Yoshida, Keimei
Saku, Keita
Kamada, Kazuhiro
Abe, Kohtaro
Tanaka-Ishikawa, Mariko
Tohyama, Takeshi
Nishikawa, Takuya
Kishi, Takuya
Sunagawa, Kenji
Tsutsui, Hiroyuki
Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
title Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
title_full Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
title_fullStr Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
title_full_unstemmed Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
title_short Electrical Vagal Nerve Stimulation Ameliorates Pulmonary Vascular Remodeling and Improves Survival in Rats With Severe Pulmonary Arterial Hypertension
title_sort electrical vagal nerve stimulation ameliorates pulmonary vascular remodeling and improves survival in rats with severe pulmonary arterial hypertension
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234524/
https://www.ncbi.nlm.nih.gov/pubmed/30456337
http://dx.doi.org/10.1016/j.jacbts.2018.07.007
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