Cargando…

Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors

SGLT2 inhibitors have profound benefits on reducing heart failure and cardiovascular mortality in individuals with type 2 diabetes, although the mechanism(s) of this benefit remain poorly understood. Because changes in cardiac bioenergetics play a critical role in the pathophysiology of heart failur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Verma, Subodh, Rawat, Sonia, Ho, Kim L., Wagg, Cory S., Zhang, Liyan, Teoh, Hwee, Dyck, John E., Uddin, Golam M., Oudit, Gavin Y., Mayoux, Eric, Lehrke, Michael, Marx, Nikolaus, Lopaschuk, Gary D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	LEADING EDGE IN TRANSLATIONAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234616/ https://www.ncbi.nlm.nih.gov/pubmed/30456329 http://dx.doi.org/10.1016/j.jacbts.2018.07.006

Ejemplares similares

Empagliflozin Prevents Worsening of Cardiac Function in an Experimental Model of Pressure Overload-Induced Heart Failure
por: Byrne, Nikole J., et al.
Publicado: (2017)

The use of chromoendoscopy for surveillance of inflammatory bowel disease
por: Lichtenstein, Gary R., et al.
Publicado: (2018)

Trade in wild animals: a disaster ignored
por: The Lancet Infectious Diseases
Publicado: (2003)

A European CDC
por: The Lancet Infectious Diseases
Publicado: (2003)

An appropriate response to SARS
por: The Lancet Infectious Diseases
Publicado: (2003)

Making our hospitals healthier places
por: The Lancet Infectious Diseases
Publicado: (2004)

Original research in The Lancet Infectious Diseases
por: The Lancet Infectious Diseases
Publicado: (2010)

Are you ready for the next influenza pandemic?
por: The Lancet Infectious Diseases
Publicado: (2005)

A new public health world order
por: The Lancet Infectious Diseases
Publicado: (2004)

Resolution of Inflammation Through the Lipoxin and ALX/FPR2 Receptor Pathway Protects Against Abdominal Aortic Aneurysms
por: Petri, Marcelo H., et al.
Publicado: (2018)

Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis
por: Teague, Heather L., et al.
Publicado: (2019)

Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis
por: Bowler, Meghan A., et al.
Publicado: (2019)

The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
por: Beddingfield, Brandon J., et al.
Publicado: (2020)

On Our Doorstep, A Precious Cargo From MSCs: The Role of Extracellular Vesicles in Stem Cell Therapy
por: Cooke, John P.
Publicado: (2020)

Rejuvenation of Senescent Endothelial Progenitor Cells by Extracellular Vesicles Derived From Mesenchymal Stromal Cells
por: Wang, Liyong, et al.
Publicado: (2020)

Integrating Integrins: A New Way to Increase Our COVID-19 Armamentarium?
por: Ross, Robert S.
Publicado: (2021)

Homophilic Interaction Between Transmembrane-JAM-A and Soluble JAM-A Regulates Thrombo-Inflammation: Implications for Coronary Artery Disease
por: Rath, Dominik, et al.
Publicado: (2022)

Jam-A Unleashed Incites Thromboinflammatory Coronary Artery Disease
por: Koenen, Rory R., et al.
Publicado: (2022)

Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection
por: Brumback, Brittany D., et al.
Publicado: (2022)

Cardiac Pericytes: Underappreciated Targets of SARS-CoV-2
por: Das, Mitali, et al.
Publicado: (2023)

PCSK9 Promotes Hypoxia-Induced EC Pyroptosis by Regulating Smac Mitochondrion-Cytoplasm Translocation in Critical Limb Ischemia
por: Zhang, Meixin, et al.
Publicado: (2023)

Assessment of Autophagy Markers Suggests Increased Activity Following LVAD Therapy
por: Martin, Thomas G., et al.
Publicado: (2023)

PCSK9-Inhibition to Quench Vascular Injury in Chronic Limb Threatening Ischemia
por: Okazaki, Ross, et al.
Publicado: (2023)

Autophagy in the LVAD-Supported Heart: A Sign of Hope or a Marker of Unloading
por: Rawnsley, David R., et al.
Publicado: (2023)

Are anticoagulants still indicated in pulmonary arterial hypertension?
por: Olschewski, Horst, et al.
Publicado: (2018)

Early intervention: should we conduct therapeutic trials for mild pulmonary hypertension before onset of symptoms?
por: Huston, Jessica H., et al.
Publicado: (2019)

United States Pulmonary Hypertension Scientific Registry (USPHSR): rationale, design, and clinical implications
por: Elliott, C. Gregory, et al.
Publicado: (2019)

Extracellular vesicles released from p18 overexpressing pulmonary endothelial cells are barrier protective – potential implications for acute respiratory distress syndrome
por: Harrington, Elizabeth O., et al.
Publicado: (2020)

Pulmonary vasodilators: beyond the bounds of pulmonary arterial hypertension therapy in COVID-19
por: Franco, Veronica, et al.
Publicado: (2020)

Transplanting COVID-19–Positive Donor Hearts: A Previous Threat, Now an Opportunity
por: Schlendorf, Kelly H., et al.
Publicado: (2023)

Precision Medicine: Solving the Mystery of Myocarditis in the Aftermath of SARS-CoV-2
por: Feldman, Arthur M., et al.
Publicado: (2023)

Baseline neutrophil‐to‐lymphocyte ratio and efficacy of SGLT2 inhibition with empagliflozin on cardiac remodelling
por: Verma, Raj, et al.
Publicado: (2023)

TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation
por: McGrath, Emmet E., et al.
Publicado: (2011)

Kidney transplantation: analysis of the expression and T cell-mediated activation of latent TGF-β
por: Willet, Joseph D. P., et al.
Publicado: (2013)

Analysis of the transcriptional networks underpinning the activation of murine macrophages by inflammatory mediators
por: Raza, Sobia, et al.
Publicado: (2014)

Langerin-expressing dendritic cells in human tissues are related to CD1c(+) dendritic cells and distinct from Langerhans cells and CD141(high) XCR1(+) dendritic cells
por: Bigley, Venetia, et al.
Publicado: (2015)

Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
por: Standing, Ariane S. I., et al.
Publicado: (2017)

IL‐4 induces a suppressive IL‐10‐producing CD8(+) T cell population via a Cdkn2a‐dependent mechanism
por: Zhao, Yapu, et al.
Publicado: (2013)

Frontline Science: Employing enzymatic treatment options for management of ocular biofilm‐based infections
por: Kugadas, Abirami, et al.
Publicado: (2019)

Frontline Science: Endotoxin‐induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst
por: Grondman, Inge, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_olslks1f47vu9hgi99tp8gms32