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Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis

BACKGROUND: Vascular dementia is the second most common type of dementia that causes cognitive dysfunction. Acupuncture, an ancient therapy, has been mentioned for the treatment of vascular dementia in previous studies. This study aimed to evaluate the effects of acupuncture in animal models of vasc...

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Autores principales: Zhang, Ze-Yu, Liu, Zhe, Deng, Hui-Hui, Chen, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234685/
https://www.ncbi.nlm.nih.gov/pubmed/30424749
http://dx.doi.org/10.1186/s12906-018-2345-z
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author Zhang, Ze-Yu
Liu, Zhe
Deng, Hui-Hui
Chen, Qin
author_facet Zhang, Ze-Yu
Liu, Zhe
Deng, Hui-Hui
Chen, Qin
author_sort Zhang, Ze-Yu
collection PubMed
description BACKGROUND: Vascular dementia is the second most common type of dementia that causes cognitive dysfunction. Acupuncture, an ancient therapy, has been mentioned for the treatment of vascular dementia in previous studies. This study aimed to evaluate the effects of acupuncture in animal models of vascular dementia. METHODS: Experimental animal studies of treating vascular dementia with acupuncture were gathered from Embase, PubMed and Ovid Medline (R) from the dates of the databases’ creation to December 2016. We adopted the CAMARADES 10-item checklist to evaluate the quality of the included studies. The Morris water maze test was considered as an outcome measure. The software Stata12.0 was used for the meta-analysis. Heterogeneity was examined using I(2) statistics, and we conducted subgroup analyses to determine the causes of heterogeneity for escape latency and duration in original platform. RESULTS: Sixteen studies involving 363 animals met the inclusion criteria. The included studies scored between 4 and 8 points, and the mean was 5.44. The results of the meta-analysis indicated remarkable differences with acupuncture on increasing the duration in the former platform quadrant both in EO models (SMD = 1.56, 95% CI: 1.02 ~ 2.11; p < 0.00001) and 2-VO models (SMD 4.29, 95% CI 3.23 ~ 5.35; p < 0.00001) compared with the control groups. CONCLUSIONS: Acupuncture may be effective in improving cognitive function in vascular dementia animal models. The mechanisms of acupuncture for vascular dementia are multiple such as anti-apoptosis, antioxidative stress reaction, and metabolism enhancing of glucose and oxygen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12906-018-2345-z) contains supplementary material, which is available to authorized users.
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spelling pubmed-62346852018-11-20 Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis Zhang, Ze-Yu Liu, Zhe Deng, Hui-Hui Chen, Qin BMC Complement Altern Med Research Article BACKGROUND: Vascular dementia is the second most common type of dementia that causes cognitive dysfunction. Acupuncture, an ancient therapy, has been mentioned for the treatment of vascular dementia in previous studies. This study aimed to evaluate the effects of acupuncture in animal models of vascular dementia. METHODS: Experimental animal studies of treating vascular dementia with acupuncture were gathered from Embase, PubMed and Ovid Medline (R) from the dates of the databases’ creation to December 2016. We adopted the CAMARADES 10-item checklist to evaluate the quality of the included studies. The Morris water maze test was considered as an outcome measure. The software Stata12.0 was used for the meta-analysis. Heterogeneity was examined using I(2) statistics, and we conducted subgroup analyses to determine the causes of heterogeneity for escape latency and duration in original platform. RESULTS: Sixteen studies involving 363 animals met the inclusion criteria. The included studies scored between 4 and 8 points, and the mean was 5.44. The results of the meta-analysis indicated remarkable differences with acupuncture on increasing the duration in the former platform quadrant both in EO models (SMD = 1.56, 95% CI: 1.02 ~ 2.11; p < 0.00001) and 2-VO models (SMD 4.29, 95% CI 3.23 ~ 5.35; p < 0.00001) compared with the control groups. CONCLUSIONS: Acupuncture may be effective in improving cognitive function in vascular dementia animal models. The mechanisms of acupuncture for vascular dementia are multiple such as anti-apoptosis, antioxidative stress reaction, and metabolism enhancing of glucose and oxygen. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12906-018-2345-z) contains supplementary material, which is available to authorized users. BioMed Central 2018-11-13 /pmc/articles/PMC6234685/ /pubmed/30424749 http://dx.doi.org/10.1186/s12906-018-2345-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Ze-Yu
Liu, Zhe
Deng, Hui-Hui
Chen, Qin
Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
title Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
title_full Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
title_fullStr Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
title_full_unstemmed Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
title_short Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis
title_sort effects of acupuncture on vascular dementia (vd) animal models: a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234685/
https://www.ncbi.nlm.nih.gov/pubmed/30424749
http://dx.doi.org/10.1186/s12906-018-2345-z
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