G2019S LRRK2 Increases Stress Susceptibility Through Inhibition of DAF-16 Nuclear Translocation in a 14-3-3 Associated-Manner in Caenorhabditis elegans

Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson’s disease (PD). Oxidative stress plays a key role in the pathogenesis of PD. Mutations in LRRK2 have been shown to increase susceptibility to oxidative stress. To explore mechanisms underlying susceptibility to...

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Detalles Bibliográficos
Autores principales: Long, Simei, Guo, Wenyuan, Hu, Sophie, Su, Fengjuan, Zeng, Yixuan, Zeng, Jinsheng, Tan, Eng-King, Ross, Christopher A., Pei, Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234837/
https://www.ncbi.nlm.nih.gov/pubmed/30464741
http://dx.doi.org/10.3389/fnins.2018.00782

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