Cargando…

The Structure of the Human Respiratory Syncytial Virus M2-1 Protein Bound to the Interaction Domain of the Phosphoprotein P Defines the Orientation of the Complex

Human respiratory syncytial virus (HRSV) is a negative-stranded RNA virus that causes a globally prevalent respiratory infection, which can cause life-threatening illness, particularly in the young, elderly, and immunocompromised. HRSV multiplication depends on replication and transcription of the H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Selvaraj, Muniyandi, Yegambaram, Kavestri, Todd, Eleanor J. A. A., Richard, Charles-Adrien, Dods, Rachel L., Pangratiou, Georgia M., Trinh, Chi H., Moul, Sophie L., Murphy, James C., Mankouri, Jamel, Éléouët, Jean-François, Barr, John N., Edwards, Thomas A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234862/ https://www.ncbi.nlm.nih.gov/pubmed/30425144 http://dx.doi.org/10.1128/mBio.01554-18

Ejemplares similares

Structure and Functional Analysis of the RNA- and Viral Phosphoprotein-Binding Domain of Respiratory Syncytial Virus M2-1 Protein
por: Blondot, Marie-Lise, et al.
Publicado: (2012)

TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection
por: Pearson, Hayley, et al.
Publicado: (2021)

Interactions between the Nucleoprotein and the Phosphoprotein of Pneumoviruses: Structural Insight for Rational Design of Antivirals
por: Decool, Hortense, et al.
Publicado: (2021)

Investigation of the Fuzzy Complex between RSV Nucleoprotein and Phosphoprotein to Optimize an Inhibition Assay by Fluorescence Polarization
por: Khodjoyan, Silva, et al.
Publicado: (2022)

Quantitative investigation of the affinity of human respiratory syncytial virus phosphoprotein C-terminus binding to nucleocapsid protein
por: Shapiro, Adam B, et al.
Publicado: (2014)

The RNA Replication Site of Tula Orthohantavirus Resides within a Remodelled Golgi Network
por: Davies, Katherine A., et al.
Publicado: (2020)

A Structural and Dynamic Analysis of the Partially Disordered Polymerase-Binding Domain in RSV Phosphoprotein
por: Cardone, Christophe, et al.
Publicado: (2021)

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro
por: Galloux, Marie, et al.
Publicado: (2020)

Importance of RNA length for in vitro encapsidation by the nucleoprotein of human respiratory syncytial virus
por: Gonnin, Lorène, et al.
Publicado: (2022)

Medicago PhosphoProtein Database: a repository for Medicago truncatula phosphoprotein data
por: Rose, Christopher M., et al.
Publicado: (2012)

Structural Disorder within Paramyxoviral Nucleoproteins and Phosphoproteins in Their Free and Bound Forms: From Predictions to Experimental Assessment
por: Habchi, Johnny, et al.
Publicado: (2015)

Structural landscape of the respiratory syncytial virus nucleocapsids
por: Gonnin, Lorène, et al.
Publicado: (2023)

Serine Phosphorylation of the Hepatitis C Virus NS5A Protein Controls the Establishment of Replication Complexes
por: Ross-Thriepland, Douglas, et al.
Publicado: (2014)

Identification of potassium and calcium channel inhibitors as modulators of polyomavirus endosomal trafficking
por: Dobson, Samuel J., et al.
Publicado: (2020)

Bunyavirus requirement for endosomal K(+) reveals new roles of cellular ion channels during infection
por: Hover, Samantha, et al.
Publicado: (2018)

Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities
por: Sutto-Ortiz, Priscila, et al.
Publicado: (2023)

Reply to Rameix-Welti, “No Incongruity in Respiratory Syncytial Virus M2-1 Protein Remaining Bound to Viral mRNAs during Their Entire Life Time”
por: Edwards, Thomas A., et al.
Publicado: (2019)

Gene optimization leads to robust expression of human respiratory syncytial virus nucleoprotein and phosphoprotein in human cells and induction of humoral immunity in mice
por: Simabuco, Fernando M., et al.
Publicado: (2009)

Pyrophosphorylation via selective phosphoprotein derivatization
por: Marmelstein, Alan M., et al.
Publicado: (2018)

Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K(+) during entry
por: Hover, Samantha, et al.
Publicado: (2023)

The Nucleoprotein and Phosphoprotein of Measles Virus
por: Guseva, Serafima, et al.
Publicado: (2019)

Ion Channels as Therapeutic Targets for Viral Infections: Further Discoveries and Future Perspectives
por: Charlton, Frank W., et al.
Publicado: (2020)

Chikungunya virus requires cellular chloride channels for efficient genome replication
por: Müller, Marietta, et al.
Publicado: (2019)

Mapping phosphoproteins in Mycoplasma genitalium and Mycoplasma pneumoniae
por: Su, Hsun-Cheng, et al.
Publicado: (2007)

Structure of an Enzyme-Derived Phosphoprotein Recognition Domain
por: Johnston, Christopher A., et al.
Publicado: (2012)

Structure of the Respiratory Syncytial Virus Polymerase Complex
por: Gilman, Morgan S.A., et al.
Publicado: (2019)

The respiratory syncytial virus nucleoprotein–RNA complex forms a left-handed helical nucleocapsid
por: Bakker, Saskia E., et al.
Publicado: (2013)

Targeting the Respiratory Syncytial Virus N(0)-P Complex with Constrained α-Helical Peptides in Cells and Mice
por: Galloux, Marie, et al.
Publicado: (2020)

Determining the Orientation and Localization of Membrane-Bound Peptides
por: Hohlweg, Walter, et al.
Publicado: (2012)

Reversion mutations in phosphoprotein P of a codon-pair-deoptimized human respiratory syncytial virus confer increased transcription, immunogenicity, and genetic stability without loss of attenuation
por: Chen, Jessica W., et al.
Publicado: (2021)

Hardening of Respiratory Syncytial Virus Inclusion Bodies by Cyclopamine Proceeds through Perturbation of the Interactions of the M2-1 Protein with RNA and the P Protein
por: Diot, Cédric, et al.
Publicado: (2023)

Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus
por: Punch, Emma K., et al.
Publicado: (2018)

The Insertion of Fluorescent Proteins in a Variable Region of Respiratory Syncytial Virus L Polymerase Results in Fluorescent and Functional Enzymes But with Reduced Activities
por: Fix, Jenna, et al.
Publicado: (2011)

Phosphoprotein analysis: from proteins to proteomes
por: Delom, Frédéric, et al.
Publicado: (2006)

Molecular Evolution of Phosphoprotein Phosphatases in Drosophila
por: Miskei, Márton, et al.
Publicado: (2011)

Golgi phosphoprotein 2 in physiology and in diseases
por: Kim, Ha-Jeong, et al.
Publicado: (2012)

Designed Phosphoprotein Recognition in Escherichia coli
por: Sawyer, Nicholas, et al.
Publicado: (2014)

Visualizing the replication of respiratory syncytial virus in cells and in living mice
por: Rameix-Welti, Marie-Anne, et al.
Publicado: (2014)

Impact of Cytokines and Phosphoproteins in Response to Chronic Joint Infection
por: Prince, Nicole, et al.
Publicado: (2020)

Sub-Nucleocapsid Nanoparticles: A Nasal Vaccine against Respiratory Syncytial Virus
por: Roux, Xavier, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_a4s214pn64hg9730gak9lpps6h