Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia

Fanconi anemia (FA) causes bone marrow failure early during childhood, and recent studies indicate that a hematopoietic defect could begin in utero. We performed a unique kinetics study of hematopoiesis in Fancg(−/−) mouse embryos, between the early embryonic day 11.5 (E11.5) to E12.5 developmental...

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Detalles Bibliográficos
Autores principales: Domenech, Carine, Maillard, Loïc, Rousseau, Alix, Guidez, Fabien, Petit, Laurence, Pla, Marika, Clay, Denis, Guimiot, Fabien, Sanfilippo, Sandra, Jacques, Sebastien, de la Grange, Pierre, Robil, Noémie, Soulier, Jean, Souyri, Michèle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234961/
https://www.ncbi.nlm.nih.gov/pubmed/30449320
http://dx.doi.org/10.1016/j.stemcr.2018.10.001

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