Species difference in paclitaxel disposition correlated with poor pharmacological efficacy translation from mice to humans

BACKGROUND: Paclitaxel (PTX) products currently approved by the Food and Drug Administration include Kolliphor EL-paclitaxel micelles (KoEL-paclitaxel, Taxol) and nanoparticle albumin-bound paclitaxel (nab-paclitaxel, Abraxane). Despite containing the same cytotoxic agent, different PTX formulations...

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Detalles Bibliográficos
Autores principales: Li, Ying Fei, Zhang, Chengyue, Zhou, Simon, He, Miao, Zhang, Huixia, Chen, Nianhang, Li, Feng, Luan, Xin, Pai, Manjunath, Yuan, Hebao, Sun, Duxin, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235005/
https://www.ncbi.nlm.nih.gov/pubmed/30519122
http://dx.doi.org/10.2147/CPAA.S185449

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