Cargando…
Loss of TXNIP enhances peritoneal metastasis and can be abrogated by dual TORC1/2 inhibition
Peritoneal metastasis (PM) is a debilitating consequence of multiple cancers. As cancer cells lose tonic signaling related to attachment dependence, critical morphologic shifts result in alteration of the transcriptome. Identifying key genes associated with this transformation may lead to targeted t...
Autores principales: | Spaeth-Cook, Douglas, Burch, Mark, Belton, Robin, Demoret, Bryce, Grosenbacher, Nicholas, David, Jason, Stets, Colin, Cohen, David, Shakya, Reena, Hays, John L., Chen, James L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235015/ https://www.ncbi.nlm.nih.gov/pubmed/30479697 http://dx.doi.org/10.18632/oncotarget.26281 |
Ejemplares similares
-
Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma
por: Seligson, Nathan D., et al.
Publicado: (2019) -
MDM2-Dependent Rewiring of Metabolomic and Lipidomic Profiles in Dedifferentiated Liposarcoma Models
por: Patt, Andrew, et al.
Publicado: (2020) -
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
por: Faes, Seraina, et al.
Publicado: (2016) -
Enhanced Oxidative DNA-Damage in Peritoneal Dialysis Patients via the TXNIP/TRX Axis
por: Oberacker, Tina, et al.
Publicado: (2022) -
Dual regulation of TxNIP by ChREBP and FoxO1 in liver
por: Noblet, Benedicte, et al.
Publicado: (2021)