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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
Antibody-drug conjugates (ADCs) used nowadays in clinical practice are mixtures of antibody molecules linked to a varying number of toxins at different positions. Preclinical studies have shown that the therapeutic index of these traditional ADCs can be improved by the site-specific linkage of toxin...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MyJove Corporation
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235180/ https://www.ncbi.nlm.nih.gov/pubmed/30272643 http://dx.doi.org/10.3791/58066 |