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Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review

Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation. Anti-TNF biological therapy has been considered a breakthrough in the treatment of chronic autoimmune diseases, such as rheumatoid arthritis (RA). In this review, because of the major involvement of...

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Autores principales: Davignon, Jean-Luc, Rauwel, Benjamin, Degboé, Yannick, Constantin, Arnaud, Boyer, Jean-Fredéric, Kruglov, Andrey, Cantagrel, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235207/
https://www.ncbi.nlm.nih.gov/pubmed/30314507
http://dx.doi.org/10.1186/s13075-018-1725-6
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author Davignon, Jean-Luc
Rauwel, Benjamin
Degboé, Yannick
Constantin, Arnaud
Boyer, Jean-Fredéric
Kruglov, Andrey
Cantagrel, Alain
author_facet Davignon, Jean-Luc
Rauwel, Benjamin
Degboé, Yannick
Constantin, Arnaud
Boyer, Jean-Fredéric
Kruglov, Andrey
Cantagrel, Alain
author_sort Davignon, Jean-Luc
collection PubMed
description Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation. Anti-TNF biological therapy has been considered a breakthrough in the treatment of chronic autoimmune diseases, such as rheumatoid arthritis (RA). In this review, because of the major involvement of T cells in RA pathogenesis, we discuss the effects of anti-TNF biotherapy on T-cell responses in RA patients. We also outline the potential fields for future research in the area of anti-TNF therapy in RA. This could be useful to better understand the therapeutic efficiency and the side effects that are encountered in RA patients. Better targeting of T cells in RA could help set more specific anti-TNF strategies and develop prediction tools for response.
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spelling pubmed-62352072018-11-20 Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review Davignon, Jean-Luc Rauwel, Benjamin Degboé, Yannick Constantin, Arnaud Boyer, Jean-Fredéric Kruglov, Andrey Cantagrel, Alain Arthritis Res Ther Review Tumor necrosis factor (TNF) is a pleiotropic cytokine involved in many aspects of immune regulation. Anti-TNF biological therapy has been considered a breakthrough in the treatment of chronic autoimmune diseases, such as rheumatoid arthritis (RA). In this review, because of the major involvement of T cells in RA pathogenesis, we discuss the effects of anti-TNF biotherapy on T-cell responses in RA patients. We also outline the potential fields for future research in the area of anti-TNF therapy in RA. This could be useful to better understand the therapeutic efficiency and the side effects that are encountered in RA patients. Better targeting of T cells in RA could help set more specific anti-TNF strategies and develop prediction tools for response. BioMed Central 2018-10-12 2018 /pmc/articles/PMC6235207/ /pubmed/30314507 http://dx.doi.org/10.1186/s13075-018-1725-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Davignon, Jean-Luc
Rauwel, Benjamin
Degboé, Yannick
Constantin, Arnaud
Boyer, Jean-Fredéric
Kruglov, Andrey
Cantagrel, Alain
Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
title Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
title_full Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
title_fullStr Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
title_full_unstemmed Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
title_short Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
title_sort modulation of t-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235207/
https://www.ncbi.nlm.nih.gov/pubmed/30314507
http://dx.doi.org/10.1186/s13075-018-1725-6
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