Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy

BACKGROUND: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules modulating myofibroblast differentiation and proli...

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Detalles Bibliográficos
Autores principales: Di Benedetto, Paola, Liakouli, Vasiliki, Ruscitti, Piero, Berardicurti, Onorina, Carubbi, Francesco, Panzera, Noemi, Di Bartolomeo, Salvatore, Guggino, Giuliana, Ciccia, Francesco, Triolo, Giovanni, Cipriani, Paola, Giacomelli, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235209/
https://www.ncbi.nlm.nih.gov/pubmed/30285896
http://dx.doi.org/10.1186/s13075-018-1719-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235209/
https://www.ncbi.nlm.nih.gov/pubmed/30285896
http://dx.doi.org/10.1186/s13075-018-1719-4

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