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Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study

BACKGROUND: Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid levels of BDNF. In this study, we explored the association between BDNF gene...

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Autores principales: Park, Dong-Jin, Kim, Seong-Ho, Nah, Seong-Su, Lee, Ji Hyun, Kim, Seong-Kyu, Lee, Yeon-Ah, Hong, Seung-Jae, Kim, Hyun-Sook, Lee, Hye-Soon, Kim, Hyoun Ah, Joung, Chung-Il, Kim, Sang-Hyon, Lee, Shin-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235218/
https://www.ncbi.nlm.nih.gov/pubmed/30285822
http://dx.doi.org/10.1186/s13075-018-1726-5
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author Park, Dong-Jin
Kim, Seong-Ho
Nah, Seong-Su
Lee, Ji Hyun
Kim, Seong-Kyu
Lee, Yeon-Ah
Hong, Seung-Jae
Kim, Hyun-Sook
Lee, Hye-Soon
Kim, Hyoun Ah
Joung, Chung-Il
Kim, Sang-Hyon
Lee, Shin-Seok
author_facet Park, Dong-Jin
Kim, Seong-Ho
Nah, Seong-Su
Lee, Ji Hyun
Kim, Seong-Kyu
Lee, Yeon-Ah
Hong, Seung-Jae
Kim, Hyun-Sook
Lee, Hye-Soon
Kim, Hyoun Ah
Joung, Chung-Il
Kim, Sang-Hyon
Lee, Shin-Seok
author_sort Park, Dong-Jin
collection PubMed
description BACKGROUND: Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid levels of BDNF. In this study, we explored the association between BDNF gene polymorphisms and FM susceptibility and the severity of symptoms. METHODS: In total, 409 patients with FM and 423 healthy controls in 10 medical centers were enrolled from the Korean nationwide FM survey. The alleles and genotypes at 10 positions in the BDNF gene were genotyped. RESULTS: The allele and genotype frequencies of BDNF rs11030104 differed significantly between the patients with FM and the controls (P = 0.031). The GG genotype of rs11030104 had a protective effect against FM (P = 0.016), and the G allele of rs11030104 was negatively associated with the presence of FM compared with the A allele (P = 0.013). In comparison, although the allele and genotype frequencies of BDNF rs12273539 did not differ between the two groups, the TT genotype of BDNF rs12273539 was associated with susceptibility to FM (P = 0.038). Haplotype analyses implied that some BDNF haplotypes have a protective effect against FM. Finally, several genotypes and haplotypes of the BDNF gene contributed to specific symptoms of FM. CONCLUSIONS: This study is the first to evaluate the associations between BDNF gene polymorphisms and FM. Our results imply that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to, and contribute to the symptoms of, FM.
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spelling pubmed-62352182018-11-20 Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study Park, Dong-Jin Kim, Seong-Ho Nah, Seong-Su Lee, Ji Hyun Kim, Seong-Kyu Lee, Yeon-Ah Hong, Seung-Jae Kim, Hyun-Sook Lee, Hye-Soon Kim, Hyoun Ah Joung, Chung-Il Kim, Sang-Hyon Lee, Shin-Seok Arthritis Res Ther Research Article BACKGROUND: Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of fibromyalgia (FM); in this regard, patients with FM have altered blood and cerebrospinal fluid levels of BDNF. In this study, we explored the association between BDNF gene polymorphisms and FM susceptibility and the severity of symptoms. METHODS: In total, 409 patients with FM and 423 healthy controls in 10 medical centers were enrolled from the Korean nationwide FM survey. The alleles and genotypes at 10 positions in the BDNF gene were genotyped. RESULTS: The allele and genotype frequencies of BDNF rs11030104 differed significantly between the patients with FM and the controls (P = 0.031). The GG genotype of rs11030104 had a protective effect against FM (P = 0.016), and the G allele of rs11030104 was negatively associated with the presence of FM compared with the A allele (P = 0.013). In comparison, although the allele and genotype frequencies of BDNF rs12273539 did not differ between the two groups, the TT genotype of BDNF rs12273539 was associated with susceptibility to FM (P = 0.038). Haplotype analyses implied that some BDNF haplotypes have a protective effect against FM. Finally, several genotypes and haplotypes of the BDNF gene contributed to specific symptoms of FM. CONCLUSIONS: This study is the first to evaluate the associations between BDNF gene polymorphisms and FM. Our results imply that some BDNF single-nucleotide polymorphisms and haplotypes are associated with susceptibility to, and contribute to the symptoms of, FM. BioMed Central 2018-10-03 2018 /pmc/articles/PMC6235218/ /pubmed/30285822 http://dx.doi.org/10.1186/s13075-018-1726-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Park, Dong-Jin
Kim, Seong-Ho
Nah, Seong-Su
Lee, Ji Hyun
Kim, Seong-Kyu
Lee, Yeon-Ah
Hong, Seung-Jae
Kim, Hyun-Sook
Lee, Hye-Soon
Kim, Hyoun Ah
Joung, Chung-Il
Kim, Sang-Hyon
Lee, Shin-Seok
Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
title Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
title_full Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
title_fullStr Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
title_full_unstemmed Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
title_short Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study
title_sort association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a korean population: a multicenter study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235218/
https://www.ncbi.nlm.nih.gov/pubmed/30285822
http://dx.doi.org/10.1186/s13075-018-1726-5
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