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Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis

BACKGROUND: This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation of new syndesmophytes over 2 years. METHODS: One hundred and nineteen patients fulfilling the imaging arm of the Assessment of Spondy...

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Autores principales: Kim, Hyoung Rae, Hong, Yeon Sik, Park, Sung-Hwan, Ju, Ji Hyeon, Kang, Kwi Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235222/
https://www.ncbi.nlm.nih.gov/pubmed/30326956
http://dx.doi.org/10.1186/s13075-018-1731-8
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author Kim, Hyoung Rae
Hong, Yeon Sik
Park, Sung-Hwan
Ju, Ji Hyeon
Kang, Kwi Young
author_facet Kim, Hyoung Rae
Hong, Yeon Sik
Park, Sung-Hwan
Ju, Ji Hyeon
Kang, Kwi Young
author_sort Kim, Hyoung Rae
collection PubMed
description BACKGROUND: This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation of new syndesmophytes over 2 years. METHODS: One hundred and nineteen patients fulfilling the imaging arm of the Assessment of SpondyloArthritis International Society axSpA criteria were enrolled. All patients were under 50 years of age. The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) was assessed by two trained readers blinded to the patients’ data. BMD (lumbar spine, femoral neck or total hip) at baseline was assessed using dual-energy absorptiometry. Low BMD was defined as Z score ≤ − 2.0. Spinal radiographic progression was defined as worsening of the mSASSS by ≥ 2 points over 2 years. Logistic regression analyses were performed to identify predictors associated with development of new syndesmophytes and spinal radiographic progression. RESULTS: At baseline, 19 (16%) patients had low BMD. New syndesmophytes had developed in 22 (21%) patients at 2-year follow-up. New syndesmophyte formation after 2 years occurred more in patients with low BMD than in those with normal BMD (p = 0.047). In the multivariable analysis, current smoking, existing syndesmophytes and low BMD at baseline were associated with spinal radiographic progression (OR (95% CI) 3.0 (1.1, 7.7), 4.6 (1.8, 11.8) and 3.6 (1.2, 11.2), respectively). The presence of syndesmophytes at baseline and low BMD were predictors of new syndesmophytes over the following 2 years (OR (95% CI) 5.5 (2.0, 15.2) and 3.6 (1.1, 11.8), respectively). CONCLUSIONS: Low BMD and existing syndesmophytes at baseline were independently associated with the development of new syndesmophytes in young axSpA patients.
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spelling pubmed-62352222018-11-20 Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis Kim, Hyoung Rae Hong, Yeon Sik Park, Sung-Hwan Ju, Ji Hyeon Kang, Kwi Young Arthritis Res Ther Research Article BACKGROUND: This study aimed to investigate whether the presence of low bone mineral density (BMD) in patients with axial spondyloarthritis (axSpA) predicts formation of new syndesmophytes over 2 years. METHODS: One hundred and nineteen patients fulfilling the imaging arm of the Assessment of SpondyloArthritis International Society axSpA criteria were enrolled. All patients were under 50 years of age. The modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) was assessed by two trained readers blinded to the patients’ data. BMD (lumbar spine, femoral neck or total hip) at baseline was assessed using dual-energy absorptiometry. Low BMD was defined as Z score ≤ − 2.0. Spinal radiographic progression was defined as worsening of the mSASSS by ≥ 2 points over 2 years. Logistic regression analyses were performed to identify predictors associated with development of new syndesmophytes and spinal radiographic progression. RESULTS: At baseline, 19 (16%) patients had low BMD. New syndesmophytes had developed in 22 (21%) patients at 2-year follow-up. New syndesmophyte formation after 2 years occurred more in patients with low BMD than in those with normal BMD (p = 0.047). In the multivariable analysis, current smoking, existing syndesmophytes and low BMD at baseline were associated with spinal radiographic progression (OR (95% CI) 3.0 (1.1, 7.7), 4.6 (1.8, 11.8) and 3.6 (1.2, 11.2), respectively). The presence of syndesmophytes at baseline and low BMD were predictors of new syndesmophytes over the following 2 years (OR (95% CI) 5.5 (2.0, 15.2) and 3.6 (1.1, 11.8), respectively). CONCLUSIONS: Low BMD and existing syndesmophytes at baseline were independently associated with the development of new syndesmophytes in young axSpA patients. BioMed Central 2018-10-16 2018 /pmc/articles/PMC6235222/ /pubmed/30326956 http://dx.doi.org/10.1186/s13075-018-1731-8 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Kim, Hyoung Rae
Hong, Yeon Sik
Park, Sung-Hwan
Ju, Ji Hyeon
Kang, Kwi Young
Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
title Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
title_full Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
title_fullStr Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
title_full_unstemmed Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
title_short Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
title_sort low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235222/
https://www.ncbi.nlm.nih.gov/pubmed/30326956
http://dx.doi.org/10.1186/s13075-018-1731-8
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