Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Two chemotypes were examined in vitro with CYPs 3A4 and 2C19 by molecular docking, metabolic profiles, and intrinsic clearance deuterium isotope effects with specifically deuterated form to assess the potential for enhancement of pharmacokinetic parameters. The results show the complexity of deutera...

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Detalles Bibliográficos
Autores principales: Sun, Hao, Piotrowski, David W., Orr, Suvi T. M., Warmus, Joseph S., Wolford, Angela C., Coffey, Steven B., Futatsugi, Kentaro, Zhang, Yinsheng, Vaz, Alfin D. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235261/
https://www.ncbi.nlm.nih.gov/pubmed/30427871
http://dx.doi.org/10.1371/journal.pone.0206279

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