The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity. STING is modified by several types of polyubiquitin chains. Here, we report that the deubiquitinase CYLD sustains STING signaling by stabilizing the STING protein. CYLD deficiency promoted the K48-linked...

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Detalles Bibliográficos
Autores principales: Zhang, Lele, Wei, Ning, Cui, Ye, Hong, Ze, Liu, Xing, Wang, Qiang, Li, Senlin, Liu, Heng, Yu, Huansha, Cai, Yanni, Wang, Quanyi, Zhu, Juanjuan, Meng, Wei, Chen, Zhengjun, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235404/
https://www.ncbi.nlm.nih.gov/pubmed/30388174
http://dx.doi.org/10.1371/journal.ppat.1007435

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