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Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation
A third of the global population relies heavily upon traditional or folk medicines, such as the African shrub Mallotus oppositifolius. Here, we used pharmacological screening and electrophysiological analysis in combination with in silico docking and site-directed mutagenesis to elucidate the effect...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235520/ https://www.ncbi.nlm.nih.gov/pubmed/30443601 http://dx.doi.org/10.1126/sciadv.aav0824 |