Physical positioning markedly enhances brain transduction after intrathecal AAV9 infusion

Several neurological disorders may benefit from gene therapy. However, even when using the lead vector candidate for intrathecal administration, adeno-associated virus serotype 9 (AAV9), the strength and distribution of gene transfer to the brain are inconsistent. On the basis of preliminary observa...

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Detalles Bibliográficos
Autores principales: Castle, Michael J., Cheng, Yuhsiang, Asokan, Aravind, Tuszynski, Mark H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235539/
https://www.ncbi.nlm.nih.gov/pubmed/30443600
http://dx.doi.org/10.1126/sciadv.aau9859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235539/
https://www.ncbi.nlm.nih.gov/pubmed/30443600
http://dx.doi.org/10.1126/sciadv.aau9859

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