The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety

Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5’-diphosphate-glucuronosyltransferases. Herein, we discuss recent...

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Detalles Bibliográficos
Autores principales: Ching, Nathan R, Alzghari, Amna K, Alzghari, Saeed K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235651/
https://www.ncbi.nlm.nih.gov/pubmed/30443442
http://dx.doi.org/10.7759/cureus.3133
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author Ching, Nathan R
Alzghari, Amna K
Alzghari, Saeed K
author_facet Ching, Nathan R
Alzghari, Amna K
Alzghari, Saeed K
author_sort Ching, Nathan R
collection PubMed
description Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5’-diphosphate-glucuronosyltransferases. Herein, we discuss recent findings regarding the pharmacogenetics of uridine 5’-diphosphate-glucuronosyltransferase 2B15 (UGT2B15), lorazepam, and its role in the treatment of anxiety.
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spelling pubmed-62356512018-11-15 The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety Ching, Nathan R Alzghari, Amna K Alzghari, Saeed K Cureus Genetics Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5’-diphosphate-glucuronosyltransferases. Herein, we discuss recent findings regarding the pharmacogenetics of uridine 5’-diphosphate-glucuronosyltransferase 2B15 (UGT2B15), lorazepam, and its role in the treatment of anxiety. Cureus 2018-08-13 /pmc/articles/PMC6235651/ /pubmed/30443442 http://dx.doi.org/10.7759/cureus.3133 Text en Copyright © 2018, Ching et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Genetics
Ching, Nathan R
Alzghari, Amna K
Alzghari, Saeed K
The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
title The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
title_full The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
title_fullStr The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
title_full_unstemmed The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
title_short The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
title_sort relationship of ugt2b15 pharmacogenetics and lorazepam for anxiety
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235651/
https://www.ncbi.nlm.nih.gov/pubmed/30443442
http://dx.doi.org/10.7759/cureus.3133
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