Sulforaphane metabolites reduce resistance to paclitaxel via microtubule disruption

Long treatment with paclitaxel (PTX) might increase resistance and side-effects causing a failure in cancer chemotherapy. Here we uncovered that either sulforaphane-cysteine (SFN-Cys) or sulforaphane-N-acetyl-cysteine (SFN-NAC) induced apoptosis via phosphorylated ERK1/2-mediated upregulation of 26 ...

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Detalles Bibliográficos
Autores principales: Wang, Yalin, Zhou, Yan, Zheng, Zhongnan, Li, Juntao, Yan, Yuting, Wu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235886/
https://www.ncbi.nlm.nih.gov/pubmed/30429459
http://dx.doi.org/10.1038/s41419-018-1174-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235886/
https://www.ncbi.nlm.nih.gov/pubmed/30429459
http://dx.doi.org/10.1038/s41419-018-1174-9

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