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Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage. AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236043/ https://www.ncbi.nlm.nih.gov/pubmed/30455753 http://dx.doi.org/10.3889/oamjms.2018.309 |
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author | Mohamed, Albasheer Abdelmalik Abbas, Mohammed Yousif Alharbi, Hajed Babiker, Ali Yousif |
author_facet | Mohamed, Albasheer Abdelmalik Abbas, Mohammed Yousif Alharbi, Hajed Babiker, Ali Yousif |
author_sort | Mohamed, Albasheer Abdelmalik |
collection | PubMed |
description | BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage. AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesions to improve the diagnosis that may help in better management and prevention of disease. MATERIAL AND METHODS: Fifty-eight formalin fixed paraffin blocks from diagnosed cases of prostatic tumours with different grade, and stages were included in this study. Ki-67 expression was examined immunohistochemically by using monoclonal mouse anti-human Ki67 IS626. The results were correlated with Gleason score and tumour differentiation and stage. RESULTS: The frequency of histological types was as follow: 11 cases of benign prostate, atic hyperplasia (19%) and 47 cases of prostatic cancer (81%). Our results stated that prostatic adenocarcinoma among Sudanese patients was of low grade which means tumours are less aggressive. Furthermore, the findings demonstrate that Ki-67 expression in prostatic carcinoma smears was correlated significantly with the degree of Gleason score (P < 0.05). CONCLUSIONS: We found that the prostatic adenocarcinoma among Sudanese patients was less aggressive. Furthermore, Ki-67 expression was proportional to the grade of a tumour and it was a useful prognostic and diagnostic biomarker. |
format | Online Article Text |
id | pubmed-6236043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-62360432018-11-19 Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients Mohamed, Albasheer Abdelmalik Abbas, Mohammed Yousif Alharbi, Hajed Babiker, Ali Yousif Open Access Maced J Med Sci Basic Science BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage. AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesions to improve the diagnosis that may help in better management and prevention of disease. MATERIAL AND METHODS: Fifty-eight formalin fixed paraffin blocks from diagnosed cases of prostatic tumours with different grade, and stages were included in this study. Ki-67 expression was examined immunohistochemically by using monoclonal mouse anti-human Ki67 IS626. The results were correlated with Gleason score and tumour differentiation and stage. RESULTS: The frequency of histological types was as follow: 11 cases of benign prostate, atic hyperplasia (19%) and 47 cases of prostatic cancer (81%). Our results stated that prostatic adenocarcinoma among Sudanese patients was of low grade which means tumours are less aggressive. Furthermore, the findings demonstrate that Ki-67 expression in prostatic carcinoma smears was correlated significantly with the degree of Gleason score (P < 0.05). CONCLUSIONS: We found that the prostatic adenocarcinoma among Sudanese patients was less aggressive. Furthermore, Ki-67 expression was proportional to the grade of a tumour and it was a useful prognostic and diagnostic biomarker. Republic of Macedonia 2018-10-20 /pmc/articles/PMC6236043/ /pubmed/30455753 http://dx.doi.org/10.3889/oamjms.2018.309 Text en Copyright: © 2018 Albasheer Abdelmalik Mohamed, Mohammed Yousif Abbas, Hajed Alharbi, Ali Yousif Babiker. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). |
spellingShingle | Basic Science Mohamed, Albasheer Abdelmalik Abbas, Mohammed Yousif Alharbi, Hajed Babiker, Ali Yousif Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients |
title | Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients |
title_full | Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients |
title_fullStr | Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients |
title_full_unstemmed | Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients |
title_short | Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients |
title_sort | assessment of expression of ki-67 in benign and malignant prostatic lesions among sudanese patients |
topic | Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236043/ https://www.ncbi.nlm.nih.gov/pubmed/30455753 http://dx.doi.org/10.3889/oamjms.2018.309 |
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