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Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients

BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage. AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesi...

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Autores principales: Mohamed, Albasheer Abdelmalik, Abbas, Mohammed Yousif, Alharbi, Hajed, Babiker, Ali Yousif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236043/
https://www.ncbi.nlm.nih.gov/pubmed/30455753
http://dx.doi.org/10.3889/oamjms.2018.309
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author Mohamed, Albasheer Abdelmalik
Abbas, Mohammed Yousif
Alharbi, Hajed
Babiker, Ali Yousif
author_facet Mohamed, Albasheer Abdelmalik
Abbas, Mohammed Yousif
Alharbi, Hajed
Babiker, Ali Yousif
author_sort Mohamed, Albasheer Abdelmalik
collection PubMed
description BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage. AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesions to improve the diagnosis that may help in better management and prevention of disease. MATERIAL AND METHODS: Fifty-eight formalin fixed paraffin blocks from diagnosed cases of prostatic tumours with different grade, and stages were included in this study. Ki-67 expression was examined immunohistochemically by using monoclonal mouse anti-human Ki67 IS626. The results were correlated with Gleason score and tumour differentiation and stage. RESULTS: The frequency of histological types was as follow: 11 cases of benign prostate, atic hyperplasia (19%) and 47 cases of prostatic cancer (81%). Our results stated that prostatic adenocarcinoma among Sudanese patients was of low grade which means tumours are less aggressive. Furthermore, the findings demonstrate that Ki-67 expression in prostatic carcinoma smears was correlated significantly with the degree of Gleason score (P < 0.05). CONCLUSIONS: We found that the prostatic adenocarcinoma among Sudanese patients was less aggressive. Furthermore, Ki-67 expression was proportional to the grade of a tumour and it was a useful prognostic and diagnostic biomarker.
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spelling pubmed-62360432018-11-19 Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients Mohamed, Albasheer Abdelmalik Abbas, Mohammed Yousif Alharbi, Hajed Babiker, Ali Yousif Open Access Maced J Med Sci Basic Science BACKGROUND: Prostatic cancer is one of the most common cancers of males in a Sudanese population. The early detection is very important, as it is only curable at an early stage. AIM: The objective of this study was to investigate the expression pattern of Ki-67 in benign and malignant prostatic lesions to improve the diagnosis that may help in better management and prevention of disease. MATERIAL AND METHODS: Fifty-eight formalin fixed paraffin blocks from diagnosed cases of prostatic tumours with different grade, and stages were included in this study. Ki-67 expression was examined immunohistochemically by using monoclonal mouse anti-human Ki67 IS626. The results were correlated with Gleason score and tumour differentiation and stage. RESULTS: The frequency of histological types was as follow: 11 cases of benign prostate, atic hyperplasia (19%) and 47 cases of prostatic cancer (81%). Our results stated that prostatic adenocarcinoma among Sudanese patients was of low grade which means tumours are less aggressive. Furthermore, the findings demonstrate that Ki-67 expression in prostatic carcinoma smears was correlated significantly with the degree of Gleason score (P < 0.05). CONCLUSIONS: We found that the prostatic adenocarcinoma among Sudanese patients was less aggressive. Furthermore, Ki-67 expression was proportional to the grade of a tumour and it was a useful prognostic and diagnostic biomarker. Republic of Macedonia 2018-10-20 /pmc/articles/PMC6236043/ /pubmed/30455753 http://dx.doi.org/10.3889/oamjms.2018.309 Text en Copyright: © 2018 Albasheer Abdelmalik Mohamed, Mohammed Yousif Abbas, Hajed Alharbi, Ali Yousif Babiker. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).
spellingShingle Basic Science
Mohamed, Albasheer Abdelmalik
Abbas, Mohammed Yousif
Alharbi, Hajed
Babiker, Ali Yousif
Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
title Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
title_full Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
title_fullStr Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
title_full_unstemmed Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
title_short Assessment of Expression of Ki-67 in Benign and Malignant Prostatic Lesions among Sudanese Patients
title_sort assessment of expression of ki-67 in benign and malignant prostatic lesions among sudanese patients
topic Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236043/
https://www.ncbi.nlm.nih.gov/pubmed/30455753
http://dx.doi.org/10.3889/oamjms.2018.309
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