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Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort

OBJECTIVE: This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). METHODS: We analyzed data from women infected with the human papillomavirus (HPV) who p...

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Autores principales: So, Kyeong A, Kim, Seon Ah, Lee, Yoo Kyung, Lee, In Ho, Lee, Ki Heon, Rhee, Jee Eun, Kee, Mee Kyung, Cho, Chi Heum, Hong, Sung Ran, Hwang, Chang Sun, Jeong, Mi Seon, Kim, Ki Tae, Ki, Moran, Hur, Soo Young, Park, Jong Sup, Kim, Tae Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236089/
https://www.ncbi.nlm.nih.gov/pubmed/30474012
http://dx.doi.org/10.5468/ogs.2018.61.6.662
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author So, Kyeong A
Kim, Seon Ah
Lee, Yoo Kyung
Lee, In Ho
Lee, Ki Heon
Rhee, Jee Eun
Kee, Mee Kyung
Cho, Chi Heum
Hong, Sung Ran
Hwang, Chang Sun
Jeong, Mi Seon
Kim, Ki Tae
Ki, Moran
Hur, Soo Young
Park, Jong Sup
Kim, Tae Jin
author_facet So, Kyeong A
Kim, Seon Ah
Lee, Yoo Kyung
Lee, In Ho
Lee, Ki Heon
Rhee, Jee Eun
Kee, Mee Kyung
Cho, Chi Heum
Hong, Sung Ran
Hwang, Chang Sun
Jeong, Mi Seon
Kim, Ki Tae
Ki, Moran
Hur, Soo Young
Park, Jong Sup
Kim, Tae Jin
author_sort So, Kyeong A
collection PubMed
description OBJECTIVE: This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). METHODS: We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing. RESULTS: Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P<0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01–17.00). CONCLUSION: The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression.
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publisher Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society
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spelling pubmed-62360892018-11-25 Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort So, Kyeong A Kim, Seon Ah Lee, Yoo Kyung Lee, In Ho Lee, Ki Heon Rhee, Jee Eun Kee, Mee Kyung Cho, Chi Heum Hong, Sung Ran Hwang, Chang Sun Jeong, Mi Seon Kim, Ki Tae Ki, Moran Hur, Soo Young Park, Jong Sup Kim, Tae Jin Obstet Gynecol Sci Original Article OBJECTIVE: This study was to identify the risk factors for cytological progression in women with atypical squamous cells of undetermined significance (ASC-US) or low-grade squamous intraepithelial lesions (LSIL). METHODS: We analyzed data from women infected with the human papillomavirus (HPV) who participated in the Korean HPV cohort study. The cohort recruited women aged 20–60 years with abnormal cervical cytology (ASC-US or LSIL) from April 2010. All women were followed-up at every 6-month intervals with cervical cytology and HPV DNA testing. RESULTS: Of the 1,158 women included, 654 (56.5%) and 504 (43.5%) women showed ASC-US and LSIL, respectively. At the time of enrollment, 143 women tested positive for HPV 16 (85 single and 58 multiple infections). Cervical cytology performed in the HPV 16-positive women showed progression in 27%, no change in 23%, and regression in 50% of the women at the six-month follow-up. The progression rate associated with HPV 16 infection was higher than that with infection caused by other HPV types (relative risk [RR], 1.75; 95% confidence interval [CI], 1.08–2.84; P=0.028). The cytological progression rate in women with persistent HPV 16 infection was higher than that in women with incidental or cleared infections (P<0.001). Logistic regression analysis showed a significant relationship between cigarette smoking and cytological progression (RR, 4.15; 95% CI, 1.01–17.00). CONCLUSION: The cytological progression rate in HPV 16-positive women with ASC-US or LSIL is higher than that in women infected with other HPV types. Additionally, cigarette smoking may play a role in cytological progression. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2018-11 2018-10-15 /pmc/articles/PMC6236089/ /pubmed/30474012 http://dx.doi.org/10.5468/ogs.2018.61.6.662 Text en Copyright © 2018 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
So, Kyeong A
Kim, Seon Ah
Lee, Yoo Kyung
Lee, In Ho
Lee, Ki Heon
Rhee, Jee Eun
Kee, Mee Kyung
Cho, Chi Heum
Hong, Sung Ran
Hwang, Chang Sun
Jeong, Mi Seon
Kim, Ki Tae
Ki, Moran
Hur, Soo Young
Park, Jong Sup
Kim, Tae Jin
Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
title Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
title_full Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
title_fullStr Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
title_full_unstemmed Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
title_short Risk factors for cytological progression in HPV 16 infected women with ASC-US or LSIL: The Korean HPV cohort
title_sort risk factors for cytological progression in hpv 16 infected women with asc-us or lsil: the korean hpv cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236089/
https://www.ncbi.nlm.nih.gov/pubmed/30474012
http://dx.doi.org/10.5468/ogs.2018.61.6.662
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