Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice

AIM: Immunotherapies blocking the CD47‐SIRPα pathway by targeting CD47 enhance macrophage phagocytosis of neoplastic cells in mouse models. As SIRPα exhibits relatively restricted tissue expression, SIRPα antagonists may be better tolerated than agents targeting CD47, which is ubiquitously expressed...

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Detalles Bibliográficos
Autores principales: Abe, Tomoyuki, Tanaka, Yuka, Piao, Jinlian, Tanimine, Naoki, Oue, Naohide, Hinoi, Takao, Garcia, Noel Verjan, Miyasaka, Masayuki, Matozaki, Takashi, Yasui, Wataru, Ohdan, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236110/
https://www.ncbi.nlm.nih.gov/pubmed/30460349
http://dx.doi.org/10.1002/ags3.12205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236110/
https://www.ncbi.nlm.nih.gov/pubmed/30460349
http://dx.doi.org/10.1002/ags3.12205

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