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Peripheral artery disease and osteoporosis: Not only age-related
Osteoporosis and atherosclerosis are two chronic degenerative diseases that share several biochemical pathways and risk factors. Previous studies have associated osteoporosis with carotid atherosclerosis, cardiovascular mortality and stroke, but data on the relationship with peripheral artery diseas...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236267/ https://www.ncbi.nlm.nih.gov/pubmed/30272311 http://dx.doi.org/10.3892/mmr.2018.9512 |
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author | Gaudio, Agostino Xourafa, Anastasia Rapisarda, Rosario Castellino, Pietro Signorelli, Salvatore Santo |
author_facet | Gaudio, Agostino Xourafa, Anastasia Rapisarda, Rosario Castellino, Pietro Signorelli, Salvatore Santo |
author_sort | Gaudio, Agostino |
collection | PubMed |
description | Osteoporosis and atherosclerosis are two chronic degenerative diseases that share several biochemical pathways and risk factors. Previous studies have associated osteoporosis with carotid atherosclerosis, cardiovascular mortality and stroke, but data on the relationship with peripheral artery disease are few and conflicting. The OPG/RANK/RANKL system and Wnt/beta catenin signaling seem to be deeply involved in the pathogenesis of bone alterations and atherosclerotic processes also affect arteries of the lower extremities. Hypovitaminosis D could also play a role in the relationship of these two diseases. New and larger studies are necessary to shed light on this association and to design new drugs able to act in both these chronic degenerative diseases. |
format | Online Article Text |
id | pubmed-6236267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-62362672018-11-19 Peripheral artery disease and osteoporosis: Not only age-related Gaudio, Agostino Xourafa, Anastasia Rapisarda, Rosario Castellino, Pietro Signorelli, Salvatore Santo Mol Med Rep Review Osteoporosis and atherosclerosis are two chronic degenerative diseases that share several biochemical pathways and risk factors. Previous studies have associated osteoporosis with carotid atherosclerosis, cardiovascular mortality and stroke, but data on the relationship with peripheral artery disease are few and conflicting. The OPG/RANK/RANKL system and Wnt/beta catenin signaling seem to be deeply involved in the pathogenesis of bone alterations and atherosclerotic processes also affect arteries of the lower extremities. Hypovitaminosis D could also play a role in the relationship of these two diseases. New and larger studies are necessary to shed light on this association and to design new drugs able to act in both these chronic degenerative diseases. D.A. Spandidos 2018-12 2018-09-27 /pmc/articles/PMC6236267/ /pubmed/30272311 http://dx.doi.org/10.3892/mmr.2018.9512 Text en Copyright: © Gaudio et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Gaudio, Agostino Xourafa, Anastasia Rapisarda, Rosario Castellino, Pietro Signorelli, Salvatore Santo Peripheral artery disease and osteoporosis: Not only age-related |
title | Peripheral artery disease and osteoporosis: Not only age-related |
title_full | Peripheral artery disease and osteoporosis: Not only age-related |
title_fullStr | Peripheral artery disease and osteoporosis: Not only age-related |
title_full_unstemmed | Peripheral artery disease and osteoporosis: Not only age-related |
title_short | Peripheral artery disease and osteoporosis: Not only age-related |
title_sort | peripheral artery disease and osteoporosis: not only age-related |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236267/ https://www.ncbi.nlm.nih.gov/pubmed/30272311 http://dx.doi.org/10.3892/mmr.2018.9512 |
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