Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme

By specifically targeting sponges likely to contain oroidin derivatives, we have, for the first time, identified Australian sponges that contain sceptrin (2) and related compounds. Using a simple extraction technique and HPLC (with a photodiode array detector) in combination with LC-MS and MS-MS we...

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Detalles Bibliográficos
Autores principales: Hao, Eleanor, Fromont, Jane, Jardine, Daniel, Karuso, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236369/
http://dx.doi.org/10.3390/60100130
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author Hao, Eleanor
Fromont, Jane
Jardine, Daniel
Karuso, Peter
author_facet Hao, Eleanor
Fromont, Jane
Jardine, Daniel
Karuso, Peter
author_sort Hao, Eleanor
collection PubMed
description By specifically targeting sponges likely to contain oroidin derivatives, we have, for the first time, identified Australian sponges that contain sceptrin (2) and related compounds. Using a simple extraction technique and HPLC (with a photodiode array detector) in combination with LC-MS and MS-MS we have been able to quickly identify known compounds and flag the presence of some new compounds in the extracts. Further work will entail isolation and structure elucidation of the new compounds and collection of fresh Agelas sp.1 with the aim of isolating the enzyme that catalyses the [2 + 2] dimerisation or oroidin to sceptrin
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spelling pubmed-62363692018-11-19 Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme Hao, Eleanor Fromont, Jane Jardine, Daniel Karuso, Peter Molecules Article By specifically targeting sponges likely to contain oroidin derivatives, we have, for the first time, identified Australian sponges that contain sceptrin (2) and related compounds. Using a simple extraction technique and HPLC (with a photodiode array detector) in combination with LC-MS and MS-MS we have been able to quickly identify known compounds and flag the presence of some new compounds in the extracts. Further work will entail isolation and structure elucidation of the new compounds and collection of fresh Agelas sp.1 with the aim of isolating the enzyme that catalyses the [2 + 2] dimerisation or oroidin to sceptrin MDPI 2001-01-16 /pmc/articles/PMC6236369/ http://dx.doi.org/10.3390/60100130 Text en © 2001 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Hao, Eleanor
Fromont, Jane
Jardine, Daniel
Karuso, Peter
Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme
title Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme
title_full Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme
title_fullStr Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme
title_full_unstemmed Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme
title_short Natural Products From Sponges of the Genus Agelas - on the Trail of a [2+2]-Photoaddition Enzyme
title_sort natural products from sponges of the genus agelas - on the trail of a [2+2]-photoaddition enzyme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236369/
http://dx.doi.org/10.3390/60100130
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