Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡

The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo-[3,4-b][1,4]diazepines (3). Structures of all...

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Autores principales: Insuasty, Braulio, Rodríguez, Ricaurte, Quiroga, Jairo, Abonía, Rodrigo, Martínez, Roberto, Toscano, Alfredo, Angeles, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236406/
http://dx.doi.org/10.3390/60800710
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author Insuasty, Braulio
Rodríguez, Ricaurte
Quiroga, Jairo
Abonía, Rodrigo
Martínez, Roberto
Toscano, Alfredo
Angeles, E.
author_facet Insuasty, Braulio
Rodríguez, Ricaurte
Quiroga, Jairo
Abonía, Rodrigo
Martínez, Roberto
Toscano, Alfredo
Angeles, E.
author_sort Insuasty, Braulio
collection PubMed
description The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo-[3,4-b][1,4]diazepines (3). Structures of all products were consistent with their IR, (1)H-NMR, (13)C-NMR and MS spectral data. X-ray crystallography data confirm the assigned structures.
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spelling pubmed-62364062018-11-19 Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡ Insuasty, Braulio Rodríguez, Ricaurte Quiroga, Jairo Abonía, Rodrigo Martínez, Roberto Toscano, Alfredo Angeles, E. Molecules Article The reaction of 4-amino-5-benzylamino-3-(4-chlorophenyl)-1H-pyrazole (1) with substituted diarylidenketones (2) constitutes a convenient synthetic route to the hitherto unknown 1-benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo-[3,4-b][1,4]diazepines (3). Structures of all products were consistent with their IR, (1)H-NMR, (13)C-NMR and MS spectral data. X-ray crystallography data confirm the assigned structures. MDPI 2001-07-31 /pmc/articles/PMC6236406/ http://dx.doi.org/10.3390/60800710 Text en © 2001 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Insuasty, Braulio
Rodríguez, Ricaurte
Quiroga, Jairo
Abonía, Rodrigo
Martínez, Roberto
Toscano, Alfredo
Angeles, E.
Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
title Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
title_full Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
title_fullStr Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
title_full_unstemmed Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
title_short Synthesis of 1-Benzyl-6-(4-chlorophenyl)-2-(4-R-phenyl)-4-(4-R-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
title_sort synthesis of 1-benzyl-6-(4-chlorophenyl)-2-(4-r-phenyl)-4-(4-r-styryl)-2,3-dihydropyrazolo[3,4-b][1,4]diazepines‡
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236406/
http://dx.doi.org/10.3390/60800710
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