Niobium Pentachloride Catalysed Ring Opening of Epoxides

Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl(5) for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, de...

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Detalles Bibliográficos
Autores principales: Constantino, Mauricio Gomes, Lacerda, Valdemar, Aragão, Valquiria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2001
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236436/
http://dx.doi.org/10.3390/60900770
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author Constantino, Mauricio Gomes
Lacerda, Valdemar
Aragão, Valquiria
author_facet Constantino, Mauricio Gomes
Lacerda, Valdemar
Aragão, Valquiria
author_sort Constantino, Mauricio Gomes
collection PubMed
description Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl(5) for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested.
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spelling pubmed-62364362018-11-19 Niobium Pentachloride Catalysed Ring Opening of Epoxides Constantino, Mauricio Gomes Lacerda, Valdemar Aragão, Valquiria Molecules Article Epoxide ring opening is a frequently required transformation in Organic Synthesis. In this paper we describe the application of NbCl(5) for this purpose using three different substrates. Chlorohydrins, 1,2-diols, products containing solvent residues as well as rearrangement products are obtained, depending on both the substrate structure and reaction conditions. Rationalizations to account for some of the results are suggested. MDPI 2001-08-31 /pmc/articles/PMC6236436/ http://dx.doi.org/10.3390/60900770 Text en © 2001 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes.
spellingShingle Article
Constantino, Mauricio Gomes
Lacerda, Valdemar
Aragão, Valquiria
Niobium Pentachloride Catalysed Ring Opening of Epoxides
title Niobium Pentachloride Catalysed Ring Opening of Epoxides
title_full Niobium Pentachloride Catalysed Ring Opening of Epoxides
title_fullStr Niobium Pentachloride Catalysed Ring Opening of Epoxides
title_full_unstemmed Niobium Pentachloride Catalysed Ring Opening of Epoxides
title_short Niobium Pentachloride Catalysed Ring Opening of Epoxides
title_sort niobium pentachloride catalysed ring opening of epoxides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236436/
http://dx.doi.org/10.3390/60900770
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