Cargando…
Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position
Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene S,S-acetals (1a), S,N-acetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2001
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236452/ http://dx.doi.org/10.3390/60700621 |
_version_ | 1783371036730851328 |
---|---|
author | Al-Afaleq, Eljazi I. Abubshait, Samar A. |
author_facet | Al-Afaleq, Eljazi I. Abubshait, Samar A. |
author_sort | Al-Afaleq, Eljazi I. |
collection | PubMed |
description | Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene S,S-acetals (1a), S,N-acetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously unreported 1-[6-(p-tolyl)-pyridazin-3-yl]pyrazolo[3,4-d]pyrimidines (8, 9, 13-20) and 7-[6-( p-tolyl) pyridazin-3-yl]2-arylpyrazolo[3,4-d]1,2,4-triazolo[5,1-f]pyrimidines (10-12) which are expected to possess considerable chemical and pharmacological activities. |
format | Online Article Text |
id | pubmed-6236452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62364522018-11-20 Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position Al-Afaleq, Eljazi I. Abubshait, Samar A. Molecules Article Novel 1-[6-(p-tolyl) pyridazin-3-yl]pyrazole-o-aminonitriles (3a-c) were formed using 3-hydrazino-6-(p-tolyl)pyridazine (2) and ketene S,S-acetals (1a), S,N-acetals (1b) or tetracyanoethylene (1c). The pyrazole-o-aminonitriles (3a-c) were in turn used as precursors for the preparation of previously unreported 1-[6-(p-tolyl)-pyridazin-3-yl]pyrazolo[3,4-d]pyrimidines (8, 9, 13-20) and 7-[6-( p-tolyl) pyridazin-3-yl]2-arylpyrazolo[3,4-d]1,2,4-triazolo[5,1-f]pyrimidines (10-12) which are expected to possess considerable chemical and pharmacological activities. MDPI 2001-06-30 /pmc/articles/PMC6236452/ http://dx.doi.org/10.3390/60700621 Text en © 2001 by MDPI (http://www.mdpi.org). Reproduction is permitted for noncommercial purposes. |
spellingShingle | Article Al-Afaleq, Eljazi I. Abubshait, Samar A. Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position |
title | Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position |
title_full | Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position |
title_fullStr | Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position |
title_full_unstemmed | Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position |
title_short | Heterocyclic o-Aminonitriles: Preparation of Pyrazolo[3,4-d]-pyrimidines with Modification of the Substituents at the 1-Position |
title_sort | heterocyclic o-aminonitriles: preparation of pyrazolo[3,4-d]-pyrimidines with modification of the substituents at the 1-position |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236452/ http://dx.doi.org/10.3390/60700621 |
work_keys_str_mv | AT alafaleqeljazii heterocyclicoaminonitrilespreparationofpyrazolo34dpyrimidineswithmodificationofthesubstituentsatthe1position AT abubshaitsamara heterocyclicoaminonitrilespreparationofpyrazolo34dpyrimidineswithmodificationofthesubstituentsatthe1position |