Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain metastases (TRIO-US B-09)

BACKGROUND: Improving outcomes for patients with human epidermal growth factor 2-positive (HER2+) central nervous system (CNS) metastases remains an unmet clinical need. This trial evaluated a novel combination of everolimus, lapatinib and capecitabine for this disease. METHODS: Patients with trastu...

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Detalles Bibliográficos
Autores principales: Hurvitz, Sara, Singh, Rashi, Adams, Brad, Taguchi, Julie A., Chan, David, Dichmann, Robert A., Castrellon, Aurelio, Hu, Eddie, Berkowitz, Jonathan, Mani, Aruna, DiCarlo, Brian, Callahan, Rena, Smalberg, Ira, Wang, Xiaoyan, Meglar, Ivana, Martinez, Diego, Hobbs, Evthokia, Slamon, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236634/
https://www.ncbi.nlm.nih.gov/pubmed/30542377
http://dx.doi.org/10.1177/1758835918807339

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