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Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients

INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is becoming more common around the world and it may progress to cirrhosis and liver failure, increasing mortality risk. In hemodialysis (HD) patients, NAFLD may be a novel risk factor for their high cardiovascular mortality. Heightened oxidative...

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Autores principales: Wu, Po-Jung, Chen, Jin-Bor, Lee, Wen-Chin, Ng, Hwee-Yeong, Lien, Shu-Ching, Tsai, Pei-Ying, Wu, Chien-Hsing, Lee, Chien-Te, Chiou, Terry Ting-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236669/
https://www.ncbi.nlm.nih.gov/pubmed/30515395
http://dx.doi.org/10.1155/2018/3961748
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author Wu, Po-Jung
Chen, Jin-Bor
Lee, Wen-Chin
Ng, Hwee-Yeong
Lien, Shu-Ching
Tsai, Pei-Ying
Wu, Chien-Hsing
Lee, Chien-Te
Chiou, Terry Ting-Yu
author_facet Wu, Po-Jung
Chen, Jin-Bor
Lee, Wen-Chin
Ng, Hwee-Yeong
Lien, Shu-Ching
Tsai, Pei-Ying
Wu, Chien-Hsing
Lee, Chien-Te
Chiou, Terry Ting-Yu
author_sort Wu, Po-Jung
collection PubMed
description INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is becoming more common around the world and it may progress to cirrhosis and liver failure, increasing mortality risk. In hemodialysis (HD) patients, NAFLD may be a novel risk factor for their high cardiovascular mortality. Heightened oxidative stress is highly prevalent in HD patients. However, the relationship between oxidative stress and NAFLD in HD patients is not well defined. METHODS: We studied seventy-one stable nondiabetic HD patients. Nineteen patients had the diagnosis of NAFLD by ultrasonography. Blood levels of oxidative stress markers were measured in each patient, including thiobarbituric acid reactive substances (TBARS), free thiols, superoxide dismutase (SOD) activities, and glutathione peroxidase (GPx) activity. The copy numbers of mitochondrial DNA (mtDNA) in peripheral leukocytes were also determined. Demographic, biochemistry, and hemogram data were recorded. The two groups of patients were compared in order to determine the factors associated with NAFLD in HD patients. FINDINGS: Compared to those without NAFLD, nondiabetic HD patients with NAFLD had significantly higher mtDNA copy number and GPx levels. The two groups did not differ significantly in dialysis adequacy, hemoglobin, serum calcium, phosphorus, albumin, liver function tests, or lipid profiles. Regression analysis confirmed mtDNA copy numbers and GPx levels as two independent factors associated with NAFLD. Compared to those with polysulfone, patients dialyzed with cellulose membrane have significantly higher levels of TBARS. However, patients with or without NAFLD did not differ in their use of either dialysis membrane. DISCUSSION: Oxidative stress (represented by antioxidant defense, GPx) and mitochondrial DNA copy numbers are independently associated with fatty liver disease in nondiabetic HD patients. The diagnostic and therapeutic implications of this key observation warrant further exploration.
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spelling pubmed-62366692018-12-04 Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients Wu, Po-Jung Chen, Jin-Bor Lee, Wen-Chin Ng, Hwee-Yeong Lien, Shu-Ching Tsai, Pei-Ying Wu, Chien-Hsing Lee, Chien-Te Chiou, Terry Ting-Yu Biomed Res Int Research Article INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is becoming more common around the world and it may progress to cirrhosis and liver failure, increasing mortality risk. In hemodialysis (HD) patients, NAFLD may be a novel risk factor for their high cardiovascular mortality. Heightened oxidative stress is highly prevalent in HD patients. However, the relationship between oxidative stress and NAFLD in HD patients is not well defined. METHODS: We studied seventy-one stable nondiabetic HD patients. Nineteen patients had the diagnosis of NAFLD by ultrasonography. Blood levels of oxidative stress markers were measured in each patient, including thiobarbituric acid reactive substances (TBARS), free thiols, superoxide dismutase (SOD) activities, and glutathione peroxidase (GPx) activity. The copy numbers of mitochondrial DNA (mtDNA) in peripheral leukocytes were also determined. Demographic, biochemistry, and hemogram data were recorded. The two groups of patients were compared in order to determine the factors associated with NAFLD in HD patients. FINDINGS: Compared to those without NAFLD, nondiabetic HD patients with NAFLD had significantly higher mtDNA copy number and GPx levels. The two groups did not differ significantly in dialysis adequacy, hemoglobin, serum calcium, phosphorus, albumin, liver function tests, or lipid profiles. Regression analysis confirmed mtDNA copy numbers and GPx levels as two independent factors associated with NAFLD. Compared to those with polysulfone, patients dialyzed with cellulose membrane have significantly higher levels of TBARS. However, patients with or without NAFLD did not differ in their use of either dialysis membrane. DISCUSSION: Oxidative stress (represented by antioxidant defense, GPx) and mitochondrial DNA copy numbers are independently associated with fatty liver disease in nondiabetic HD patients. The diagnostic and therapeutic implications of this key observation warrant further exploration. Hindawi 2018-11-01 /pmc/articles/PMC6236669/ /pubmed/30515395 http://dx.doi.org/10.1155/2018/3961748 Text en Copyright © 2018 Po-Jung Wu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wu, Po-Jung
Chen, Jin-Bor
Lee, Wen-Chin
Ng, Hwee-Yeong
Lien, Shu-Ching
Tsai, Pei-Ying
Wu, Chien-Hsing
Lee, Chien-Te
Chiou, Terry Ting-Yu
Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
title Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
title_full Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
title_fullStr Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
title_full_unstemmed Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
title_short Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
title_sort oxidative stress and nonalcoholic fatty liver disease in hemodialysis patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236669/
https://www.ncbi.nlm.nih.gov/pubmed/30515395
http://dx.doi.org/10.1155/2018/3961748
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