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Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging

Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this...

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Autores principales: Tran, Vu-Long, Thakare, Vivek, Natuzzi, Marco, Moreau, Mathieu, Oudot, Alexandra, Vrigneaud, Jean-Marc, Courteau, Alan, Louis, Cédric, Roux, Stéphane, Boschetti, Frédéric, Denat, Franck, Tillement, Olivier, Lux, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236700/
https://www.ncbi.nlm.nih.gov/pubmed/30515070
http://dx.doi.org/10.1155/2018/7938267
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author Tran, Vu-Long
Thakare, Vivek
Natuzzi, Marco
Moreau, Mathieu
Oudot, Alexandra
Vrigneaud, Jean-Marc
Courteau, Alan
Louis, Cédric
Roux, Stéphane
Boschetti, Frédéric
Denat, Franck
Tillement, Olivier
Lux, François
author_facet Tran, Vu-Long
Thakare, Vivek
Natuzzi, Marco
Moreau, Mathieu
Oudot, Alexandra
Vrigneaud, Jean-Marc
Courteau, Alan
Louis, Cédric
Roux, Stéphane
Boschetti, Frédéric
Denat, Franck
Tillement, Olivier
Lux, François
author_sort Tran, Vu-Long
collection PubMed
description Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol. This functionalization strategy requires no other reactants or catalyzers and does not compromise the ultrasmall size of the particles. NODAGA-functionalized particle has been labeled with (64)Cu isotope and injected intravenously to mice bearing TS/A carcinoma tumor for biodistribution study to demonstrate its potential as a bimodal MRI/PET imaging agent. A fully integrated MRI/PET system was used to simultaneously monitor the distribution of the particle. The results showed that the functionalized particle maintained properties of a renal clearable NP which could rapidly escape through kidneys and had low retention in other organs, especially liver, even though its accumulation in the tumor was modest.
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spelling pubmed-62367002018-12-04 Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging Tran, Vu-Long Thakare, Vivek Natuzzi, Marco Moreau, Mathieu Oudot, Alexandra Vrigneaud, Jean-Marc Courteau, Alan Louis, Cédric Roux, Stéphane Boschetti, Frédéric Denat, Franck Tillement, Olivier Lux, François Contrast Media Mol Imaging Research Article Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic results. Among different types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, effective, and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on SiGdNP by a simple one-step protocol. This functionalization strategy requires no other reactants or catalyzers and does not compromise the ultrasmall size of the particles. NODAGA-functionalized particle has been labeled with (64)Cu isotope and injected intravenously to mice bearing TS/A carcinoma tumor for biodistribution study to demonstrate its potential as a bimodal MRI/PET imaging agent. A fully integrated MRI/PET system was used to simultaneously monitor the distribution of the particle. The results showed that the functionalized particle maintained properties of a renal clearable NP which could rapidly escape through kidneys and had low retention in other organs, especially liver, even though its accumulation in the tumor was modest. Hindawi 2018-11-01 /pmc/articles/PMC6236700/ /pubmed/30515070 http://dx.doi.org/10.1155/2018/7938267 Text en Copyright © 2018 Vu-Long Tran et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tran, Vu-Long
Thakare, Vivek
Natuzzi, Marco
Moreau, Mathieu
Oudot, Alexandra
Vrigneaud, Jean-Marc
Courteau, Alan
Louis, Cédric
Roux, Stéphane
Boschetti, Frédéric
Denat, Franck
Tillement, Olivier
Lux, François
Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging
title Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging
title_full Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging
title_fullStr Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging
title_full_unstemmed Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging
title_short Functionalization of Gadolinium Chelates Silica Nanoparticle through Silane Chemistry for Simultaneous MRI/(64)Cu PET Imaging
title_sort functionalization of gadolinium chelates silica nanoparticle through silane chemistry for simultaneous mri/(64)cu pet imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236700/
https://www.ncbi.nlm.nih.gov/pubmed/30515070
http://dx.doi.org/10.1155/2018/7938267
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