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A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer

Currently dynamic conformal arcs (DCA) and volumetric modulated arc therapy (VMAT) are two popular planning techniques to treat lung stereotactic body radiation therapy (SBRT) patients. Of the two, DCA has advantages in terms of multi‐leaf collimator (MLC) motion, positioning error, and delivery eff...

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Autores principales: Liu, Han, Sintay, Benjamin, Pearman, Keith, Shang, Qingyang, Hayes, Lane, Maurer, Jacqueline, Vanderstraeten, Caroline, Wiant, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236848/
https://www.ncbi.nlm.nih.gov/pubmed/30281198
http://dx.doi.org/10.1002/acm2.12450
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author Liu, Han
Sintay, Benjamin
Pearman, Keith
Shang, Qingyang
Hayes, Lane
Maurer, Jacqueline
Vanderstraeten, Caroline
Wiant, David
author_facet Liu, Han
Sintay, Benjamin
Pearman, Keith
Shang, Qingyang
Hayes, Lane
Maurer, Jacqueline
Vanderstraeten, Caroline
Wiant, David
author_sort Liu, Han
collection PubMed
description Currently dynamic conformal arcs (DCA) and volumetric modulated arc therapy (VMAT) are two popular planning techniques to treat lung stereotactic body radiation therapy (SBRT) patients. Of the two, DCA has advantages in terms of multi‐leaf collimator (MLC) motion, positioning error, and delivery efficiency. However, VMAT is often the choice when critical organ sparing becomes important. We developed a hybrid strategy to incorporate DCA component into VMAT planning, results were compared with DCA and VMAT plans. Four planning techniques were retrospectively simulated for 10 lung SBRT patients: DCA, Hybrid‐DCA (2/3 of the doses from DCA beams), Hybrid‐VMAT (2/3 of the doses from VMAT beams) and VMAT. Plan complexity was accessed by modulation complexity score (MCS). Conformity index (CI) for the planning target volume (PTV), V (20) and V (5) for the lung, V (30) for the chestwall, and maximum dose to all other critical organs were calculated. Plans were compared with regard to these metrics and measured agreement between the planned and delivered doses. DCA technique did not result in acceptable plan quality due to target location for five patients. Hybrid‐DCA produced one unacceptable plan, and Hybrid‐VMAT and VMAT produced no unacceptable plans. The CI improved with increasing VMAT usage, as did the dose sparing to critical structures. Compared to the VMAT technique, a total MU reduction of 14%, 25% and 37% were found for Hybrid‐VMAT, Hybrid‐DCA and DCA techniques for 54 Gy patient group, and 9%, 23% and 34% for 50 Gy patient group, suggesting improvement in delivery efficiency with increasing DCA usage. No significant variations of plan complexity were observed between Hybrid‐DCA and Hybrid‐VMAT (P = 0.46 from Mann–Whitney U‐test), but significant differences were found among DCA, Hybrid and VMAT (P < 0.05). Better agreements between the planned and delivered doses were found with more DCA contributions. By adding DCA components to VMAT planning, hybrid technique offers comparable dosimetry to full VMAT, while increasing delivery efficiency and minimizing MLC complexity.
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spelling pubmed-62368482018-11-20 A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer Liu, Han Sintay, Benjamin Pearman, Keith Shang, Qingyang Hayes, Lane Maurer, Jacqueline Vanderstraeten, Caroline Wiant, David J Appl Clin Med Phys Radiation Oncology Physics Currently dynamic conformal arcs (DCA) and volumetric modulated arc therapy (VMAT) are two popular planning techniques to treat lung stereotactic body radiation therapy (SBRT) patients. Of the two, DCA has advantages in terms of multi‐leaf collimator (MLC) motion, positioning error, and delivery efficiency. However, VMAT is often the choice when critical organ sparing becomes important. We developed a hybrid strategy to incorporate DCA component into VMAT planning, results were compared with DCA and VMAT plans. Four planning techniques were retrospectively simulated for 10 lung SBRT patients: DCA, Hybrid‐DCA (2/3 of the doses from DCA beams), Hybrid‐VMAT (2/3 of the doses from VMAT beams) and VMAT. Plan complexity was accessed by modulation complexity score (MCS). Conformity index (CI) for the planning target volume (PTV), V (20) and V (5) for the lung, V (30) for the chestwall, and maximum dose to all other critical organs were calculated. Plans were compared with regard to these metrics and measured agreement between the planned and delivered doses. DCA technique did not result in acceptable plan quality due to target location for five patients. Hybrid‐DCA produced one unacceptable plan, and Hybrid‐VMAT and VMAT produced no unacceptable plans. The CI improved with increasing VMAT usage, as did the dose sparing to critical structures. Compared to the VMAT technique, a total MU reduction of 14%, 25% and 37% were found for Hybrid‐VMAT, Hybrid‐DCA and DCA techniques for 54 Gy patient group, and 9%, 23% and 34% for 50 Gy patient group, suggesting improvement in delivery efficiency with increasing DCA usage. No significant variations of plan complexity were observed between Hybrid‐DCA and Hybrid‐VMAT (P = 0.46 from Mann–Whitney U‐test), but significant differences were found among DCA, Hybrid and VMAT (P < 0.05). Better agreements between the planned and delivered doses were found with more DCA contributions. By adding DCA components to VMAT planning, hybrid technique offers comparable dosimetry to full VMAT, while increasing delivery efficiency and minimizing MLC complexity. John Wiley and Sons Inc. 2018-10-03 /pmc/articles/PMC6236848/ /pubmed/30281198 http://dx.doi.org/10.1002/acm2.12450 Text en © 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Liu, Han
Sintay, Benjamin
Pearman, Keith
Shang, Qingyang
Hayes, Lane
Maurer, Jacqueline
Vanderstraeten, Caroline
Wiant, David
A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
title A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
title_full A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
title_fullStr A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
title_full_unstemmed A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
title_short A hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
title_sort hybrid planning strategy for stereotactic body radiation therapy of early stage non‐small‐cell lung cancer
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236848/
https://www.ncbi.nlm.nih.gov/pubmed/30281198
http://dx.doi.org/10.1002/acm2.12450
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