Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice

We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilat...

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Autores principales: Murtaza, Ghulam, Paddenberg, Renate, Pfeil, Uwe, Goldenberg, Anna, Mermer, Petra, Kummer, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236867/
https://www.ncbi.nlm.nih.gov/pubmed/30284509
http://dx.doi.org/10.1177/2045894018808240
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author Murtaza, Ghulam
Paddenberg, Renate
Pfeil, Uwe
Goldenberg, Anna
Mermer, Petra
Kummer, Wolfgang
author_facet Murtaza, Ghulam
Paddenberg, Renate
Pfeil, Uwe
Goldenberg, Anna
Mermer, Petra
Kummer, Wolfgang
author_sort Murtaza, Ghulam
collection PubMed
description We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation-perfusion matching at the acinar level.
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spelling pubmed-62368672018-11-19 Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice Murtaza, Ghulam Paddenberg, Renate Pfeil, Uwe Goldenberg, Anna Mermer, Petra Kummer, Wolfgang Pulm Circ Research Letter We show that genetic deficiency of the reactive oxygen species generating enzyme NADPH oxidase 4 (NOX4) impairs hypoxic pulmonary vasoconstriction in small (25–40 µm) intra-acinar, but not pre-acinar, arteries in murine precision cut lung slices. These data suggest an involvement of NOX4 in ventilation-perfusion matching at the acinar level. SAGE Publications 2018-10-04 /pmc/articles/PMC6236867/ /pubmed/30284509 http://dx.doi.org/10.1177/2045894018808240 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Murtaza, Ghulam
Paddenberg, Renate
Pfeil, Uwe
Goldenberg, Anna
Mermer, Petra
Kummer, Wolfgang
Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
title Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
title_full Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
title_fullStr Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
title_full_unstemmed Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
title_short Hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in NADPH oxidase 4 gene-deficient mice
title_sort hypoxia-induced pulmonary vasoconstriction of intra-acinar arteries is impaired in nadph oxidase 4 gene-deficient mice
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236867/
https://www.ncbi.nlm.nih.gov/pubmed/30284509
http://dx.doi.org/10.1177/2045894018808240
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