Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines

BACKGROUND: Preemptive administration of analgesic drugs reduces perceived pain and prolongs duration of antinociceptive action. Whereas several lines of evidence suggest that endomorphins, the endogenous mu-opioid agonists, attenuate acute and chronic pain at the spinal level, their preemptive anal...

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Detalles Bibliográficos
Autores principales: Zhang, Ting, Zhang, Nan, Zhang, Run, Zhao, Weidong, Chen, Yong, Wang, Zilong, Xu, Biao, Zhang, Mengna, Shi, Xuerui, Zhang, Qinqin, Guo, Yuanyuan, Xiao, Jian, Chen, Dan, Fang, Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236886/
https://www.ncbi.nlm.nih.gov/pubmed/30442166
http://dx.doi.org/10.1186/s12974-018-1358-3

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