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Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study
BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236929/ https://www.ncbi.nlm.nih.gov/pubmed/30428934 http://dx.doi.org/10.1186/s12944-018-0895-1 |
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author | Angoorani, Pooneh Khademian, Majid Ejtahed, Hanieh-Sadat Heshmat, Ramin Motlagh, Mohammad Esmaeil Vafaeenia, Mahya Shafiee, Gita Mahdivi-Gorabi, Armita Qorbani, Mostafa Kelishadi, Roya |
author_facet | Angoorani, Pooneh Khademian, Majid Ejtahed, Hanieh-Sadat Heshmat, Ramin Motlagh, Mohammad Esmaeil Vafaeenia, Mahya Shafiee, Gita Mahdivi-Gorabi, Armita Qorbani, Mostafa Kelishadi, Roya |
author_sort | Angoorani, Pooneh |
collection | PubMed |
description | BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. METHODS: This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7–18 years. MetS was defined by the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group. The analysis of receiver operating characteristic (ROC) curve was applied to determine the optimal cut-points of non-HDL-C, difference between non-HDL-C and LDL-C (Diff-C) and triglycerides (TG) to HDL-C ratio (TG/HDL-C) for the prediction of MetS. RESULTS: Overall, the study participants consisted of 3843 students (52.3% boys) with mean (±SD) age of 12.28 (3.1) years. The odds of high LDL-C, low HDL-C and MetS were increased in subjects with higher non-HDL-C, Diff-C and TG/HDL-C (P < 0.05). Non-HDL-C, Diff-C and TG/HDL-C cut-off points for predicting MetS were 120.5 mg/dl (sensitivity: 44%, specificity: 73%), 19.9 mg/dl (sensitivity: 85%, specificity: 75%) and 2.53 (sensitivity: 82%, specificity: 79%), respectively. CONCLUSIONS: This study revealed a strong association between surrogates for serum lipid profile including non-HDL-C, TG/HDL-C and Diff-C and pediatric MetS. Our findings suggest that age- and gender-specific reference values of these markers were appropriate for both risk classification and long-term control of cardiovascular events in clinical assessments. |
format | Online Article Text |
id | pubmed-6236929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-62369292018-11-20 Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study Angoorani, Pooneh Khademian, Majid Ejtahed, Hanieh-Sadat Heshmat, Ramin Motlagh, Mohammad Esmaeil Vafaeenia, Mahya Shafiee, Gita Mahdivi-Gorabi, Armita Qorbani, Mostafa Kelishadi, Roya Lipids Health Dis Research BACKGROUND: Non-high-density lipoprotein cholesterol (non-HDL-C) is considered as a valuable predictor for dyslipidemia and subclinical atherosclerosis which can be an appropriate index for identifying individuals with metabolic syndrome (MetS). OBJECTIVE: To evaluate the association between non-HDL-C MetS and determine the optimal cut-points of non-HDL-C fractions for identifying MetS in Iranian children and adolescents. METHODS: This nationwide study was conducted in the framework of the fifth survey of a national school-based surveillance program on children and adolescents aged 7–18 years. MetS was defined by the Adult Treatment Panel III (ATP III) criteria modified for the pediatric age group. The analysis of receiver operating characteristic (ROC) curve was applied to determine the optimal cut-points of non-HDL-C, difference between non-HDL-C and LDL-C (Diff-C) and triglycerides (TG) to HDL-C ratio (TG/HDL-C) for the prediction of MetS. RESULTS: Overall, the study participants consisted of 3843 students (52.3% boys) with mean (±SD) age of 12.28 (3.1) years. The odds of high LDL-C, low HDL-C and MetS were increased in subjects with higher non-HDL-C, Diff-C and TG/HDL-C (P < 0.05). Non-HDL-C, Diff-C and TG/HDL-C cut-off points for predicting MetS were 120.5 mg/dl (sensitivity: 44%, specificity: 73%), 19.9 mg/dl (sensitivity: 85%, specificity: 75%) and 2.53 (sensitivity: 82%, specificity: 79%), respectively. CONCLUSIONS: This study revealed a strong association between surrogates for serum lipid profile including non-HDL-C, TG/HDL-C and Diff-C and pediatric MetS. Our findings suggest that age- and gender-specific reference values of these markers were appropriate for both risk classification and long-term control of cardiovascular events in clinical assessments. BioMed Central 2018-11-14 /pmc/articles/PMC6236929/ /pubmed/30428934 http://dx.doi.org/10.1186/s12944-018-0895-1 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Angoorani, Pooneh Khademian, Majid Ejtahed, Hanieh-Sadat Heshmat, Ramin Motlagh, Mohammad Esmaeil Vafaeenia, Mahya Shafiee, Gita Mahdivi-Gorabi, Armita Qorbani, Mostafa Kelishadi, Roya Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study |
title | Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study |
title_full | Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study |
title_fullStr | Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study |
title_full_unstemmed | Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study |
title_short | Are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? The CASPIAN-V study |
title_sort | are non-high–density lipoprotein fractions associated with pediatric metabolic syndrome? the caspian-v study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236929/ https://www.ncbi.nlm.nih.gov/pubmed/30428934 http://dx.doi.org/10.1186/s12944-018-0895-1 |
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