Ca(2+)-dependent endoplasmic reticulum stress correlation with astrogliosis involves upregulation of KCa3.1 and inhibition of AKT/mTOR signaling

BACKGROUND: The intermediate-conductance Ca(2+)-activated K(+) channel KCa3.1 was recently shown to control the phenotype switch of reactive astrogliosis (RA) in Alzheimer’s disease (AD). METHODS: KCa3.1 channels expression and cell localization in the brains of AD patients and APP/PS1 mice model we...

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Detalles Bibliográficos
Autores principales: Yu, Zhihua, Dou, Fangfang, Wang, Yanxia, Hou, Lina, Chen, Hongzhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236981/
https://www.ncbi.nlm.nih.gov/pubmed/30442153
http://dx.doi.org/10.1186/s12974-018-1351-x

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