Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru

OBJECTIVE: The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). RESULTS: Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consumption th...

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Autores principales: Aguilar-Luis, Miguel Angel, Palacios-Cuervo, Fernando, Espinal-Reyes, Fátima, Calderón-Rivera, Andrea, Levy-Blitchtein, Saúl, Palomares-Reyes, Carlos, Silva-Caso, Wilmer, Zavaleta-Gavidia, Victor, Bazán-Mayra, Jorge, Cornejo-Tapia, Angela, del Valle-Mendoza, Juana, del Valle, Luis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236992/
https://www.ncbi.nlm.nih.gov/pubmed/30428917
http://dx.doi.org/10.1186/s13104-018-3919-z
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author Aguilar-Luis, Miguel Angel
Palacios-Cuervo, Fernando
Espinal-Reyes, Fátima
Calderón-Rivera, Andrea
Levy-Blitchtein, Saúl
Palomares-Reyes, Carlos
Silva-Caso, Wilmer
Zavaleta-Gavidia, Victor
Bazán-Mayra, Jorge
Cornejo-Tapia, Angela
del Valle-Mendoza, Juana
del Valle, Luis J.
author_facet Aguilar-Luis, Miguel Angel
Palacios-Cuervo, Fernando
Espinal-Reyes, Fátima
Calderón-Rivera, Andrea
Levy-Blitchtein, Saúl
Palomares-Reyes, Carlos
Silva-Caso, Wilmer
Zavaleta-Gavidia, Victor
Bazán-Mayra, Jorge
Cornejo-Tapia, Angela
del Valle-Mendoza, Juana
del Valle, Luis J.
author_sort Aguilar-Luis, Miguel Angel
collection PubMed
description OBJECTIVE: The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). RESULTS: Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consumption the most frequent associated factor in patients with positive PCR for H. pylori infection (93.9%). Clarithromycin resistant mutations were found in 79.6% (39/49) of the positive samples for H. pylori. The most frequent mutation was A2142G (46.9%), followed by the double-mutation A2142G–A2143G (28.6%).
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spelling pubmed-62369922018-11-23 Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru Aguilar-Luis, Miguel Angel Palacios-Cuervo, Fernando Espinal-Reyes, Fátima Calderón-Rivera, Andrea Levy-Blitchtein, Saúl Palomares-Reyes, Carlos Silva-Caso, Wilmer Zavaleta-Gavidia, Victor Bazán-Mayra, Jorge Cornejo-Tapia, Angela del Valle-Mendoza, Juana del Valle, Luis J. BMC Res Notes Research Note OBJECTIVE: The objective of this study was to determine the prevalence of clarithromycin-resistant Helicobacter pylori in asymptomatic children in a rural community of Cajamarca (northern Peru). RESULTS: Helicobacter pylori was detected in 17.2% (49/285) of the samples. Unboiled water consumption the most frequent associated factor in patients with positive PCR for H. pylori infection (93.9%). Clarithromycin resistant mutations were found in 79.6% (39/49) of the positive samples for H. pylori. The most frequent mutation was A2142G (46.9%), followed by the double-mutation A2142G–A2143G (28.6%). BioMed Central 2018-11-14 /pmc/articles/PMC6236992/ /pubmed/30428917 http://dx.doi.org/10.1186/s13104-018-3919-z Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Aguilar-Luis, Miguel Angel
Palacios-Cuervo, Fernando
Espinal-Reyes, Fátima
Calderón-Rivera, Andrea
Levy-Blitchtein, Saúl
Palomares-Reyes, Carlos
Silva-Caso, Wilmer
Zavaleta-Gavidia, Victor
Bazán-Mayra, Jorge
Cornejo-Tapia, Angela
del Valle-Mendoza, Juana
del Valle, Luis J.
Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
title Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
title_full Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
title_fullStr Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
title_full_unstemmed Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
title_short Highly clarithromycin-resistant Helicobacter pylori infection in asymptomatic children from a rural community of Cajamarca-Peru
title_sort highly clarithromycin-resistant helicobacter pylori infection in asymptomatic children from a rural community of cajamarca-peru
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236992/
https://www.ncbi.nlm.nih.gov/pubmed/30428917
http://dx.doi.org/10.1186/s13104-018-3919-z
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