Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain

A prominent role of hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels has been suggested based on their expression and (dys)function in dorsal root ganglion (DRG) neurons, being likely involved in peripheral nociception. Using HCN blockers as antinociceptive drugs is prevented by t...

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Detalles Bibliográficos
Autores principales: Dini, Leonardo, Del Lungo, Martina, Resta, Francesco, Melchiorre, Michele, Spinelli, Valentina, Di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Laurino, Annunziatina, Sartiani, Laura, Coppini, Raffaele, Mannaioni, Guido, Cerbai, Elisabetta, Romanelli, Maria Novella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237106/
https://www.ncbi.nlm.nih.gov/pubmed/30467478
http://dx.doi.org/10.3389/fphar.2018.01252

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