Acute Toxoplasma Dissemination With Encephalitis in the Era of Biological Therapies

We report the case of a 65-year-old patient with pseudolymphoma who developed acute toxoplasmosis following 6 cycles of rituximab and bendamustine therapy. Acute toxoplasmosis in the setting of biological response modifiers, rather than reactivation, is a unique unreported infection. The patient dev...

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Detalles Bibliográficos
Autores principales: Gharamti, Amal A, Rao, Amy, Pecen, Paula E, Henao-Martínez, Andrés F, Franco-Paredes, Carlos, Montoya, José G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237240/
https://www.ncbi.nlm.nih.gov/pubmed/30460322
http://dx.doi.org/10.1093/ofid/ofy259
Descripción
Sumario:We report the case of a 65-year-old patient with pseudolymphoma who developed acute toxoplasmosis following 6 cycles of rituximab and bendamustine therapy. Acute toxoplasmosis in the setting of biological response modifiers, rather than reactivation, is a unique unreported infection. The patient developed severe disease with multi-organ involvement, including retinitis, myocarditis, and myositis. We discuss the clinical findings, epidemiology, and laboratory diagnosis.

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