IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

Tumors evade immune control by creating hostile microenvironments that perturb T cell metabolism and effector function(1–4). However, it remains unclear how intratumoral T cells integrate and interpret metabolic stress signals. Here we report that ovarian cancer (OvCa), an aggressive malignancy refr...

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Detalles Bibliográficos
Autores principales: Song, Minkyung, Sandoval, Tito A., Chae, Chang-Suk, Chopra, Sahil, Tan, Chen, Rutkowski, Melanie R., Raundhal, Mahesh, Chaurio, Ricardo A., Payne, Kyle K., Konrad, Csaba, Bettigole, Sarah E., Shin, Hee Rae, Crowley, Michael J. P., Cerliani, Juan P., Kossenkov, Andrew V., Motorykin, Ievgen, Zhang, Sheng, Manfredi, Giovanni, Zamarin, Dmitriy, Holcomb, Kevin, Rodriguez, Paulo C., Rabinovich, Gabriel A., Conejo-Garcia, Jose R., Glimcher, Laurie H., Cubillos-Ruiz, Juan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237282/
https://www.ncbi.nlm.nih.gov/pubmed/30305738
http://dx.doi.org/10.1038/s41586-018-0597-x

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