The deletion of the ORF1 and ORF71 genes reduces virulence of the neuropathogenic EHV-1 strain Ab4 without compromising host immunity in horses

The equine herpesvirus type 1 (EHV-1) ORF1 and ORF71 genes have immune modulatory effects in vitro. Experimental infection of horses using virus mutants with multiple deletions including ORF1 and ORF71 showed promise as vaccine candidates against EHV-1. Here, the combined effects of ORF1 and ORF71 d...

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Detalles Bibliográficos
Autores principales: Wimer, Christine L., Schnabel, Christiane L., Perkins, Gillian, Babasyan, Susanna, Freer, Heather, Stout, Alison E., Rollins, Alicia, Osterrieder, Nikolaus, Goodman, Laura B., Glaser, Amy, Wagner, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237298/
https://www.ncbi.nlm.nih.gov/pubmed/30440016
http://dx.doi.org/10.1371/journal.pone.0206679

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