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Respiratory syncytial virus hospitalization in children in northern Spain

OBJECTIVES: Understanding respiratory syncytial virus (RSV) morbidity may help to plan health care and future vaccine recommendations. We aim to describe the characteristics and temporal distribution of children diagnosed with RSV admitted in a Spanish hospital. METHODS: Descriptive study for which...

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Autores principales: Viguria, Natividad, Martínez-Baz, Iván, Moreno-Galarraga, Laura, Sierrasesúmaga, Luis, Salcedo, Blanca, Castilla, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237306/
https://www.ncbi.nlm.nih.gov/pubmed/30439987
http://dx.doi.org/10.1371/journal.pone.0206474
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author Viguria, Natividad
Martínez-Baz, Iván
Moreno-Galarraga, Laura
Sierrasesúmaga, Luis
Salcedo, Blanca
Castilla, Jesús
author_facet Viguria, Natividad
Martínez-Baz, Iván
Moreno-Galarraga, Laura
Sierrasesúmaga, Luis
Salcedo, Blanca
Castilla, Jesús
author_sort Viguria, Natividad
collection PubMed
description OBJECTIVES: Understanding respiratory syncytial virus (RSV) morbidity may help to plan health care and future vaccine recommendations. We aim to describe the characteristics and temporal distribution of children diagnosed with RSV admitted in a Spanish hospital. METHODS: Descriptive study for which the hospital discharges of children < 5 years of age with RSV infection were analyzed. The information was extracted from the hospital discharge database of a reference pediatric hospital in northern Spain for the 2010–2011 to 2014–2015 RSV seasons. RESULTS: Six hundred and forty-seven hospitalizations of children with RSV infection were analyzed, 94% of which occurred between the second week of November and the last week of March. Most children (72%) were under one year of age and 95% were previously healthy infants. Infants born from October to December had the highest risk of hospitalization in the first year of life. The median length of hospital stay of children with and without comorbidities was six and three days, respectively. 6.5% of the hospitalized cases were admitted to the pediatric intensive care unit; this percentage was higher among children < 2 months (adjusted odds ratio 4.15; 95% confidence interval: 1.37–12.61) or with comorbidities (adjusted odds ratio 4.15; 95% confidence interval: 1.53–11.28). The case lethality was 0.3%. CONCLUSIONS: The risk of hospitalizations for RSV is high during the first year of life and increases among infants born in the fall. Being under two months of age and presenting comorbidities are the main risk factors associated to pediatric intensive care unit admission.
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spelling pubmed-62373062018-12-01 Respiratory syncytial virus hospitalization in children in northern Spain Viguria, Natividad Martínez-Baz, Iván Moreno-Galarraga, Laura Sierrasesúmaga, Luis Salcedo, Blanca Castilla, Jesús PLoS One Research Article OBJECTIVES: Understanding respiratory syncytial virus (RSV) morbidity may help to plan health care and future vaccine recommendations. We aim to describe the characteristics and temporal distribution of children diagnosed with RSV admitted in a Spanish hospital. METHODS: Descriptive study for which the hospital discharges of children < 5 years of age with RSV infection were analyzed. The information was extracted from the hospital discharge database of a reference pediatric hospital in northern Spain for the 2010–2011 to 2014–2015 RSV seasons. RESULTS: Six hundred and forty-seven hospitalizations of children with RSV infection were analyzed, 94% of which occurred between the second week of November and the last week of March. Most children (72%) were under one year of age and 95% were previously healthy infants. Infants born from October to December had the highest risk of hospitalization in the first year of life. The median length of hospital stay of children with and without comorbidities was six and three days, respectively. 6.5% of the hospitalized cases were admitted to the pediatric intensive care unit; this percentage was higher among children < 2 months (adjusted odds ratio 4.15; 95% confidence interval: 1.37–12.61) or with comorbidities (adjusted odds ratio 4.15; 95% confidence interval: 1.53–11.28). The case lethality was 0.3%. CONCLUSIONS: The risk of hospitalizations for RSV is high during the first year of life and increases among infants born in the fall. Being under two months of age and presenting comorbidities are the main risk factors associated to pediatric intensive care unit admission. Public Library of Science 2018-11-15 /pmc/articles/PMC6237306/ /pubmed/30439987 http://dx.doi.org/10.1371/journal.pone.0206474 Text en © 2018 Viguria et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Viguria, Natividad
Martínez-Baz, Iván
Moreno-Galarraga, Laura
Sierrasesúmaga, Luis
Salcedo, Blanca
Castilla, Jesús
Respiratory syncytial virus hospitalization in children in northern Spain
title Respiratory syncytial virus hospitalization in children in northern Spain
title_full Respiratory syncytial virus hospitalization in children in northern Spain
title_fullStr Respiratory syncytial virus hospitalization in children in northern Spain
title_full_unstemmed Respiratory syncytial virus hospitalization in children in northern Spain
title_short Respiratory syncytial virus hospitalization in children in northern Spain
title_sort respiratory syncytial virus hospitalization in children in northern spain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237306/
https://www.ncbi.nlm.nih.gov/pubmed/30439987
http://dx.doi.org/10.1371/journal.pone.0206474
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