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Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information

This study investigated how attending to auditory and visual information systematically changes graph theoretical measures of integration and functional connectivity between three network modules: auditory, visual, and a joint task core. Functional MRI BOLD activity was recorded while healthy volunt...

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Detalles Bibliográficos
Autores principales: Quante, Laura, Kluger, Daniel S., Bürkner, Paul C., Ekman, Matthias, Schubotz, Ricarda I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237351/
https://www.ncbi.nlm.nih.gov/pubmed/30439973
http://dx.doi.org/10.1371/journal.pone.0207119
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author Quante, Laura
Kluger, Daniel S.
Bürkner, Paul C.
Ekman, Matthias
Schubotz, Ricarda I.
author_facet Quante, Laura
Kluger, Daniel S.
Bürkner, Paul C.
Ekman, Matthias
Schubotz, Ricarda I.
author_sort Quante, Laura
collection PubMed
description This study investigated how attending to auditory and visual information systematically changes graph theoretical measures of integration and functional connectivity between three network modules: auditory, visual, and a joint task core. Functional MRI BOLD activity was recorded while healthy volunteers attended to colour and/or pitch information presented within an audiovisual stimulus sequence. Network nodes and modules were based on peak voxels of BOLD contrasts, including colour and pitch sensitive brain regions as well as the dorsal attention network. Network edges represented correlations between nodes’ activity and were computed separately for each condition. Connection strength was increased between the task and the visual module when participants attended to colour, and between the task and the auditory module when they attended to pitch. Moreover, several nodal graph measures showed consistent changes to attentional modulation in form of stronger integration of sensory regions in response to attention. Together, these findings corroborate dynamical adjustments of both modality-specific and modality-independent functional brain networks in response to task demands and their representation in graph theoretical measures.
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spelling pubmed-62373512018-12-01 Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information Quante, Laura Kluger, Daniel S. Bürkner, Paul C. Ekman, Matthias Schubotz, Ricarda I. PLoS One Research Article This study investigated how attending to auditory and visual information systematically changes graph theoretical measures of integration and functional connectivity between three network modules: auditory, visual, and a joint task core. Functional MRI BOLD activity was recorded while healthy volunteers attended to colour and/or pitch information presented within an audiovisual stimulus sequence. Network nodes and modules were based on peak voxels of BOLD contrasts, including colour and pitch sensitive brain regions as well as the dorsal attention network. Network edges represented correlations between nodes’ activity and were computed separately for each condition. Connection strength was increased between the task and the visual module when participants attended to colour, and between the task and the auditory module when they attended to pitch. Moreover, several nodal graph measures showed consistent changes to attentional modulation in form of stronger integration of sensory regions in response to attention. Together, these findings corroborate dynamical adjustments of both modality-specific and modality-independent functional brain networks in response to task demands and their representation in graph theoretical measures. Public Library of Science 2018-11-15 /pmc/articles/PMC6237351/ /pubmed/30439973 http://dx.doi.org/10.1371/journal.pone.0207119 Text en © 2018 Quante et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Quante, Laura
Kluger, Daniel S.
Bürkner, Paul C.
Ekman, Matthias
Schubotz, Ricarda I.
Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information
title Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information
title_full Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information
title_fullStr Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information
title_full_unstemmed Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information
title_short Graph measures in task-based fMRI: Functional integration during read-out of visual and auditory information
title_sort graph measures in task-based fmri: functional integration during read-out of visual and auditory information
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237351/
https://www.ncbi.nlm.nih.gov/pubmed/30439973
http://dx.doi.org/10.1371/journal.pone.0207119
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