Prelamin A causes aberrant myonuclear arrangement and results in muscle fiber weakness

Physiological and premature aging are frequently associated with an accumulation of prelamin A, a precursor of lamin A, in the nuclear envelope of various cell types. Here, we aimed to underpin the hitherto unknown mechanisms by which prelamin A alters myonuclear organization and muscle fiber functi...

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Detalles Bibliográficos
Autores principales: Levy, Yotam, Ross, Jacob A., Niglas, Marili, Snetkov, Vladimir A., Lynham, Steven, Liao, Chen-Yu, Puckelwartz, Megan J., Hsu, Yueh-Mei, McNally, Elizabeth M., Alsheimer, Manfred, Harridge, Stephen D.R., Young, Stephen G., Fong, Loren G., Español, Yaiza, Lopez-Otin, Carlos, Kennedy, Brian K., Lowe, Dawn A., Ochala, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237469/
https://www.ncbi.nlm.nih.gov/pubmed/30282816
http://dx.doi.org/10.1172/jci.insight.120920

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