Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3(+)RORγt(+) Regulatory T Cells

Foxp3(+) regulatory T cells (Treg) are essential modulators of immune responses, but the molecular mechanisms underlying their function are not fully understood. Here we show that the transcription factor Blimp-1 is a crucial regulator of the Foxp3(+)RORγt(+) Treg subset. The intrinsic expression of...

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Detalles Bibliográficos
Autores principales: Ogawa, Chihiro, Bankoti, Rashmi, Nguyen, Truc, Hassanzadeh-Kiabi, Nargess, Nadeau, Samantha, Porritt, Rebecca A., Couse, Michael, Fan, Xuemo, Dhall, Deepti, Eberl, Gerald, Ohnmacht, Caspar, Martins, Gislâine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237548/
https://www.ncbi.nlm.nih.gov/pubmed/30282028
http://dx.doi.org/10.1016/j.celrep.2018.09.016

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