Cargando…

C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast‐inducing chemokine CXCL10

The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm of innate immunity. C5a mediates proinflammatory actions via the C5a receptor C5aR1 and thereby promotes host defence, but also modulates tissue homeostasis. There is evidence that the C5a/C5aR1 axis is critic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mödinger, Yvonne, Rapp, Anna, Pazmandi, Julia, Vikman, Anna, Holzmann, Karlheinz, Haffner‐Luntzer, Melanie, Huber‐Lang, Markus, Ignatius, Anita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237570/ https://www.ncbi.nlm.nih.gov/pubmed/30247799 http://dx.doi.org/10.1111/jcmm.13873

Ejemplares similares

Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis
por: Bülow, Jasmin Maria, et al.
Publicado: (2022)

Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses
por: Sehring, Ivonne, et al.
Publicado: (2022)

Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice
por: Schoppa, Astrid M., et al.
Publicado: (2022)

Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption
por: Luntzer, Kathrin, et al.
Publicado: (2021)

Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells
por: Steppe, Lena, et al.
Publicado: (2022)

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing
por: Bergdolt, Stephanie, et al.
Publicado: (2017)

Correction: Steppe et al. Bone Mass and Osteoblast Activity Are Sex-Dependent in Mice Lacking the Estrogen Receptor α in Chondrocytes and Osteoblast Progenitor Cells. Int. J. Mol. Sci. 2022, 23, 2902
por: Steppe, Lena, et al.
Publicado: (2022)

Estrogen Receptor α Signaling in Osteoblasts is Required for Mechanotransduction in Bone Fracture Healing
por: Steppe, Lena, et al.
Publicado: (2021)

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma
por: Kaiser, Kathrin, et al.
Publicado: (2018)

A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation
por: Tschaffon, Miriam E. A., et al.
Publicado: (2021)

C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing
por: Ehrnthaller, Christian, et al.
Publicado: (2016)

Role of Mast-Cell-Derived RANKL in Ovariectomy-Induced Bone Loss in Mice
por: Fischer, Verena, et al.
Publicado: (2023)

Complement receptors C5aR1 and C5aR2 act differentially during the early immune response after bone fracture but are similarly involved in bone repair
por: Kovtun, Anna, et al.
Publicado: (2017)

Midkine-Deficiency Delays Chondrogenesis during the Early Phase of Fracture Healing in Mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2014)

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus
por: Haffner‐Luntzer, Melanie, et al.
Publicado: (2016)

Mechanobiology of bone remodeling and fracture healing in the aged organism
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2016)

Differences in Fracture Healing Between Female and Male C57BL/6J Mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2021)

Inhibition of Midkine Augments Osteoporotic Fracture Healing
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2016)

The Wnt Serpentine Receptor Frizzled-9 Regulates New Bone Formation in Fracture Healing
por: Heilmann, Aline, et al.
Publicado: (2013)

Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/osteoclast co-culture
por: Meng, Guolong, et al.
Publicado: (2019)

Influence of Low-Magnitude High-Frequency Vibration on Bone Cells and Bone Regeneration
por: Steppe, Lena, et al.
Publicado: (2020)

CXCL8 – The First Chemokine
por: Baggiolini, Marco
Publicado: (2015)

Osteoblast-Osteoclast Communication and Bone Homeostasis
por: Kim, Jung-Min, et al.
Publicado: (2020)

The inflammatory phase of fracture healing is influenced by oestrogen status in mice
por: Haffner-Luntzer, Melanie, et al.
Publicado: (2017)

Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
por: Riegger, Jana, et al.
Publicado: (2023)

Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
por: Koch, Christian, et al.
Publicado: (2022)

The chemokine CXCL13 in cerebrospinal fluid in children with Lyme neuroborreliosis
por: Henningsson, Anna J., et al.
Publicado: (2018)

Primary mouse osteoblast and osteoclast culturing and analysis
por: Chevalier, Claire, et al.
Publicado: (2021)

The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts
por: Donaubauer, Anna-Jasmina, et al.
Publicado: (2020)

Overproduction of CXC chemokines CXCL1, CXCL9, CXCL10 and CXCL12 in β-thalassemia major or patients
por: Najmaddini, Hamid, et al.
Publicado: (2014)

Role of the Complement System in the Response to Orthopedic Biomaterials
por: Mödinger, Yvonne, et al.
Publicado: (2018)

β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells
por: Huang, Zhibin, et al.
Publicado: (2019)

Correction: Interactions of the chemokines CXCL11 and CXCL12 in human tumor cells
por: Koch, Christian, et al.
Publicado: (2023)

The CXCL12/CXCR4 chemokine ligand/receptor axis in cardiovascular disease
por: Döring, Yvonne, et al.
Publicado: (2014)

The Chemokine CXCL8 in Carcinogenesis and Drug Response
por: Gales, Dominique, et al.
Publicado: (2013)

CXCL14: the Swiss army knife chemokine
por: Benarafa, Charaf, et al.
Publicado: (2015)

The significance of chemokine CXCL-8 in esophageal carcinoma
por: Łukaszewicz-Zając, Marta, et al.
Publicado: (2020)

CXCL17: The Black Sheep in the Chemokine Flock
por: Denisov, Stepan S.
Publicado: (2021)

Type-I Interferons Suppress Microglial Production of the Lymphoid Chemokine, CXCL13
por: Esen, Nilufer, et al.
Publicado: (2014)

Akt1 in Osteoblasts and Osteoclasts Controls Bone Remodeling
por: Kawamura, Naohiro, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_nhed5hqrp6bgvhbsdv3v9keu42