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Active site closure stabilizes the backtracked state of RNA polymerase

All cellular RNA polymerases (RNAP) occasionally backtrack along the template DNA as part of transcriptional proofreading and regulation. Here, we studied the mechanism of RNAP backtracking by one nucleotide using two complementary approaches that allowed us to precisely measure the occupancy and li...

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Detalles Bibliográficos
Autores principales:	Turtola, Matti, Mäkinen, Janne J, Belogurov, Georgiy A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237748/ https://www.ncbi.nlm.nih.gov/pubmed/30256972 http://dx.doi.org/10.1093/nar/gky883

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