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High-affinity RNA targets of the Survival Motor Neuron protein reveal diverse preferences for sequence and structural motifs

The Survival Motor Neuron (SMN) protein is essential for survival of all animal cells. SMN harbors a nucleic acid-binding domain and plays an important role in RNA metabolism. However, the RNA-binding property of SMN is poorly understood. Here we employ iterative in vitro selection and chemical stru...

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Detalles Bibliográficos
Autores principales:	Ottesen, Eric W, Singh, Natalia N, Luo, Diou, Singh, Ravindra N
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237763/ https://www.ncbi.nlm.nih.gov/pubmed/30165668 http://dx.doi.org/10.1093/nar/gky770

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